公开(公告)号：US20230183246A1

公开(公告)日：2023-06-15

申请号：US17926379

申请日：2021-05-13

Applicant: Purdue Research Foundation

Inventor： David Harley Thompson ,  Herman O. Sintim ,  Qingqing Qi ,  Shruti Biyani

IPC: C07D487/04 ,  C07D401/06 ,  C07D471/04 ,  B01J31/24

CPC classification number: C07D487/04 ,  C07D401/06 ,  C07D471/04 ,  B01J31/2404 ,  B01J2531/824 ,  B01J2231/32

Abstract: The present disclosure relates to a telescoped continuous flow Sonogashira coupling synthesis for some lead compounds to support in vivo studies and pre-clinical evaluation. The application of high throughput tools combined with the telescoped continuous synthesis method can enable an efficient and safe synthesis of compounds of interest involving hazardous coupling reagents such as HATU, while minimizing by-product formation.