公开(公告)号：US20220093380A1

公开(公告)日：2022-03-24

申请号：US17231224

申请日：2021-04-15

Applicant: Purdue Research Foundation

Inventor： Yu Xia ,  Zheng Ouyang ,  Xiaoxiao Ma

IPC: H01J49/04 ,  G01N1/30 ,  G01N33/92 ,  G01N30/00 ,  G01N1/40 ,  G01N30/72 ,  G01N30/88 ,  H01J49/00

Abstract: The invention generally relates to methods for analyzing a tissue sample. In certain aspects, the invention provides methods that involve obtaining a tissue sample including an unsaturated compound, conducting a radical reaction on the tissue sample that targets a carbon-carbon double bond within the unsaturated compound to thereby produce a plurality of compound isomers, subjecting the plurality of compound isomers to mass spectrometry analysis to identify a location of the carbon-carbon double bond within the unsaturated compound, and quantifying the plurality of compound isomers in order to distinguish normal tissue from diseased tissue.

公开(公告)号：US20180294148A1

公开(公告)日：2018-10-11

申请号：US15577516

申请日：2016-05-27

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Yu Xia ,  Xiaoxiao Ma

IPC: H01J49/04 ,  G01N1/30 ,  G01N30/72 ,  G01N30/88 ,  H01J49/00 ,  G01N33/92

Abstract: The invention generally relates to methods for analyzing a tissue sample. In certain aspects, the invention provides methods that involve obtaining a tissue sample including an unsaturated compound, conducting a radical reaction on the tissue sample that targets a carbon-carbon double bond within the unsaturated compound to thereby produce a plurality of compound isomers, subjecting the plurality of compound isomers to mass spectrometry analysis to identify a location of the carbon-carbon double bond within the unsaturated compound, and quantifying the plurality of compound isomers in order to distinguish normal tissue from diseased tissue.

公开(公告)号：US11037772B2

公开(公告)日：2021-06-15

申请号：US15577516

申请日：2016-05-27

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Yu Xia ,  Xiaoxiao Ma

IPC: H01J49/04 ,  G01N1/30 ,  G01N33/92 ,  G01N30/00 ,  G01N1/40 ,  G01N30/72 ,  G01N30/88 ,  H01J49/00 ,  A61B10/02 ,  G01N30/02

Abstract: The invention generally relates to methods for analyzing a tissue sample. In certain aspects, the invention provides methods that involve obtaining a tissue sample including an unsaturated compound, conducting a radical reaction on the tissue sample that targets a carbon-carbon double bond within the unsaturated compound to thereby produce a plurality of compound isomers, subjecting the plurality of compound isomers to mass spectrometry analysis to identify a location of the carbon-carbon double bond within the unsaturated compound, and quantifying the plurality of compound isomers in order to distinguish normal tissue from diseased tissue.