公开(公告)号：US20220125933A1

公开(公告)日：2022-04-28

申请号：US17310871

申请日：2020-02-28

申请人： PureTech LYT, Inc. ,  Monash University

发明人： Joseph BOLEN ,  Daniel Kenneth BONNER ,  Ketki KARANAM ,  Christopher John PORTER ,  Jamie SIMPSON ,  Natalie TREVASKIS ,  Dan ZHENG ,  Nathania LEONG ,  Garima SHARMA ,  Mitchell MCINERNEY ,  Tim QUACH ,  Sifei HAN

IPC分类号： A61K47/54 ,  A61K31/519 ,  A61K31/529 ,  A61K31/437 ,  A61K31/4985 ,  A61P35/00

摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.