公开(公告)号：US20160144020A1

公开(公告)日：2016-05-26

申请号：US14899538

申请日：2014-06-18

Applicant: QUEENSLAND UNIVERSITY OF TECHNOLOGY

Inventor： Janet Davies ,  Bradley Campbell

IPC: A61K39/36 ,  G01N33/68

CPC classification number: A61K39/36 ,  C07K14/415 ,  C07K16/16 ,  G01N33/6893 ,  G01N2333/415 ,  G01N2800/24

Abstract: Allergenic Johnson Grass proteins, antibodies thereto and encoding nucleic acids are provided, which may be used for the diagnosis and/or therapy of sensitivity to these allergenic proteins or to immunologically cross-reactive allergenic proteins. In particular, the allergenic Johnson grass proteins and nucleic acids may be used for environmental testing for airborne allergens and/or for batch standardization of diagnostic and therapeutic compositions.

Abstract translation: 提供过敏性约翰逊草蛋白，其抗体和编码核酸，其可用于诊断和/或治疗对这些变应原蛋白或免疫交叉反应性变应原蛋白的敏感性。 特别地，过敏性约翰逊草蛋白和核酸可用于空气传播过敏原的环境测试和/或用于诊断和治疗组合物的批量标准化。

公开(公告)号：US10293042B2

公开(公告)日：2019-05-21

申请号：US15705059

申请日：2017-09-14

Applicant: Queensland University of Technology

Inventor： Robyn O'Hehir ,  Janet Davies ,  Jennifer Rolland

IPC: A61K39/35 ,  C07K14/415 ,  C07K16/16 ,  G01N33/577

Abstract: The present invention relates generally to novel recombinant polypeptides of Bahia grass pollen and to genetic sequences encoding same. More particularly, the present invention is directed to Pas n 1 polypeptides and derivatives, and fragments thereof and genetic sequences encoding same. The molecules of the present invention are useful in a range of therapeutic, prophylactic and diagnostic applications including, but not limited to, applications in the context of conditions characterized by an aberrant, inappropriate or otherwise unwanted immune response to the Bahia grass pollen.

公开(公告)号：US20170276677A1

公开(公告)日：2017-09-28

申请号：US15320283

申请日：2015-06-22

Applicant: Queensland University of Technology

Inventor： Janet Davies

IPC: G01N33/569 ,  C07K14/415 ,  G01N33/68 ,  C07K16/16 ,  A61K39/36 ,  G01N33/577

CPC classification number: G01N33/56961 ,  A61K39/36 ,  C07K14/415 ,  C07K16/16 ,  C07K2317/72 ,  G01N33/577 ,  G01N33/68 ,  G01N2800/24

Abstract: Detection of grass pollen proteins such as Pas n 1, Sor h 1 and/or Cyn d 1 for the purpose of batch standardization of compositions comprising these grass pollen proteins, such as used for desensitization to these allergenic proteins. The methods may also be suitable for detecting or measuring levels of grass pollen proteins such as Pas n 1, Sor h 1 and/or Cyn d 1 in environmental samples such as air or water. Also provided is an antibody or antibody fragment engineered to bind Pas n 1 and one or a plurality of other grass pollen proteins such as Sor h 1 and/or Cyn d 1.