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1.发明公开公开(公告)号：US20240124883A1
公开(公告)日：2024-04-18
申请号：US18278255
申请日：2022-02-19
发明人： Issam Hmila , Nour Khaled Majbour , Omar El-Agnaf
IPC分类号： C12N15/115 , C12N15/10
CPC分类号： C12N15/115 , C12N15/1048 , C12N2310/16
摘要： The present disclosure, in part, relates to novel, aptamers targeting α-synuclein. The present disclosure includes methods for making and methods of using aptamers targeting α-synuclein.
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公开(公告)号：US20220089708A1
公开(公告)日：2022-03-24
申请号：US17511230
申请日：2021-10-26
IPC分类号： C07K16/18
摘要： The present specification provides a monoclonal antibody that specifically binds aggregated, non-phosphorylated α-synuclein and a hybridoma producing it. Also disclosed are methods of generating antibodies that specifically binds aggregated, non-phosphorylated α-synuclein and uses thereof. Uses of anti-α-synuclein antibody in detection and diagnostic assays, and for prophylaxis or therapy of α-synuclein-associated neurodegenerative diseases, are also disclosed.
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公开(公告)号：US20230365665A1
公开(公告)日：2023-11-16
申请号：US18027021
申请日：2021-09-17
CPC分类号： C07K16/18 , G01N33/6896 , C12N5/163 , C07K2317/14 , G01N2800/2835 , C07K2317/34 , C07K2317/76
摘要： The present specification provides a monoclonal antibody that specifically binds aggregated, non-phosphorylated α-synuclein and a hybridoma producing it. Also disclosed are methods of generating antibodies that specifically binds aggregated, non-phosphorylated α-synuclein and uses thereof. Uses of anti-α-synuclein antibody in detection and diagnostic assays, and for prophylaxis or therapy of α-synuclein-associated neurodegenerative diseases, are also disclosed.
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