公开(公告)号：US20240118292A1

公开(公告)日：2024-04-11

申请号：US18378967

申请日：2023-10-11

Applicant: Qatar Foundation for Education, Science and Community Development

Inventor： Omar El-Agnaf

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N2800/2814 ,  G01N2800/2835 ,  G01N2800/52

Abstract: The instant disclosure relates to methods for measuring disease progression in Parkinson's Disease and other neurodegenerative diseases.

公开(公告)号：US20240255530A1

公开(公告)日：2024-08-01

申请号：US18566559

申请日：2022-06-02

Applicant: Qatar Foundation for Education, Science and Community Development

Inventor： Omar El-Agnaf

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N2333/4728 ,  G01N2800/2821

Abstract: Provided are methods of diagnosis and differentiation of and between PD and DLB tissue samples.

公开(公告)号：US20240124883A1

公开(公告)日：2024-04-18

申请号：US18278255

申请日：2022-02-19

Applicant: Qatar Foundation for Education, Science and Community Development

Inventor： Issam Hmila ,  Nour Khaled Majbour ,  Omar El-Agnaf

IPC: C12N15/115 ,  C12N15/10

CPC classification number: C12N15/115 ,  C12N15/1048 ,  C12N2310/16

Abstract: The present disclosure, in part, relates to novel, aptamers targeting α-synuclein. The present disclosure includes methods for making and methods of using aptamers targeting α-synuclein.

公开(公告)号：US20230365665A1

公开(公告)日：2023-11-16

申请号：US18027021

申请日：2021-09-17

Applicant: Qatar Foundation for Education, Science and Community Development

Inventor： Omar El-Agnaf ,  Nour Khaled Majbour ,  Nishant Vaikath

IPC: C07K16/18 ,  G01N33/68 ,  C12N5/16

CPC classification number: C07K16/18 ,  G01N33/6896 ,  C12N5/163 ,  C07K2317/14 ,  G01N2800/2835 ,  C07K2317/34 ,  C07K2317/76

Abstract: The present specification provides a monoclonal antibody that specifically binds aggregated, non-phosphorylated α-synuclein and a hybridoma producing it. Also disclosed are methods of generating antibodies that specifically binds aggregated, non-phosphorylated α-synuclein and uses thereof. Uses of anti-α-synuclein antibody in detection and diagnostic assays, and for prophylaxis or therapy of α-synuclein-associated neurodegenerative diseases, are also disclosed.

公开(公告)号：US20240052022A1

公开(公告)日：2024-02-15

申请号：US18233733

申请日：2023-08-14

Applicant: Qatar Foundation for Education, Science and Community Development

Inventor： Prasanna R. Kolatkar ,  Zeyaul Islam ,  Issam Hmila ,  Nishant Vaikath ,  Omar El-Agnaf

IPC: C07K16/18 ,  G01N33/68

CPC classification number: C07K16/18 ,  G01N33/6896 ,  C07K2317/569 ,  G01N2800/2821 ,  C07K2317/76 ,  C07K2317/34 ,  G01N2800/2835

Abstract: Alpha synuclein picobodies, which are N-terminal truncations of alpha synuclein nanobodies are provided. Methods of using alpha synuclein picobodies for diagnosing and treating synucleinopathies are also provided.

公开(公告)号：US20220089708A1

公开(公告)日：2022-03-24

申请号：US17511230

申请日：2021-10-26

Applicant: Qatar Foundation for Education, Science and Community Development

Inventor： Omar El-Agnaf ,  Nour Khaled Majbour ,  Nishant Vaikath

IPC: C07K16/18

Abstract: The present specification provides a monoclonal antibody that specifically binds aggregated, non-phosphorylated α-synuclein and a hybridoma producing it. Also disclosed are methods of generating antibodies that specifically binds aggregated, non-phosphorylated α-synuclein and uses thereof. Uses of anti-α-synuclein antibody in detection and diagnostic assays, and for prophylaxis or therapy of α-synuclein-associated neurodegenerative diseases, are also disclosed.