公开(公告)号：US20130012704A1

公开(公告)日：2013-01-10

申请号：US13617881

申请日：2012-09-14

申请人： Qiang DING ,  Nathanael Schiander GRAY ,  Bing LI ,  Yi LIU ,  Taebo SIM ,  Tetsuo UNO ,  Guobao ZHANG ,  Carole Pissot Soldermann ,  Werner BREITENSTEIN ,  Guido BOLD ,  Giorgio CARAVATTI ,  Pascal FURET ,  Vito GUAGNANO ,  Marc LANG ,  Paul W. MANLEY ,  Joseph SCHOEPFER ,  Carsten SPANKA

发明人： Qiang DING ,  Nathanael Schiander GRAY ,  Bing LI ,  Yi LIU ,  Taebo SIM ,  Tetsuo UNO ,  Guobao ZHANG ,  Carole Pissot Soldermann ,  Werner BREITENSTEIN ,  Guido BOLD ,  Giorgio CARAVATTI ,  Pascal FURET ,  Vito GUAGNANO ,  Marc LANG ,  Paul W. MANLEY ,  Joseph SCHOEPFER ,  Carsten SPANKA

IPC分类号： C07D403/12 ,  C07C265/12 ,  C07D413/12 ,  C07D405/12 ,  C07D409/14 ,  C07D401/12 ,  C07D401/14 ,  C07C217/84 ,  C07D239/48

CPC分类号： C07D239/48 ,  C07D251/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.

公开(公告)号：US20130012476A1

公开(公告)日：2013-01-10

申请号：US13617733

申请日：2012-09-14

申请人： Qiang DING ,  Nathanael Schiander GRAY ,  Bing LI ,  Yi LIU ,  Taebo SIM ,  Tetsuo UNO ,  Guobao ZHANG ,  Carole Pissot Soldermann ,  Werner BREITENSTEIN ,  Guido BOLD ,  Giorgio CARAVATTI ,  Pascal FURET ,  Vito GUAGNANO ,  Marc LANG ,  Paul W. MANLEY ,  Joseph SCHOEPFER ,  Carsten SPANKA

发明人： Qiang DING ,  Nathanael Schiander GRAY ,  Bing LI ,  Yi LIU ,  Taebo SIM ,  Tetsuo UNO ,  Guobao ZHANG ,  Carole Pissot Soldermann ,  Werner BREITENSTEIN ,  Guido BOLD ,  Giorgio CARAVATTI ,  Pascal FURET ,  Vito GUAGNANO ,  Marc LANG ,  Paul W. MANLEY ,  Joseph SCHOEPFER ,  Carsten SPANKA

IPC分类号： A61K31/496 ,  A61K31/695 ,  A61K31/505 ,  A61P35/00 ,  A61K31/5377

CPC分类号： C07D239/48 ,  C07D251/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.

摘要翻译： 本发明涉及式（I）化合物，其中取代基X1，R1，R2，R3和R4具有本发明说明书中阐述和解释的含义，制备这些化合物的方法，含有它们的药物组合物 ，其任选与一种或多种其它药学活性化合物组合用于治疗对蛋白激酶活性的抑制作出反应的疾病的用途，以及治疗这种疾病的方法。