公开(公告)号：US20110118472A1

公开(公告)日：2011-05-19

申请号：US12989610

申请日：2009-01-20

申请人： Qilin Zhou ,  Shoufej Zhu ,  Shen Li ,  Lixin Wang ,  Song Song

发明人： Qilin Zhou ,  Shoufej Zhu ,  Shen Li ,  Lixin Wang ,  Song Song

IPC分类号： C07F9/653 ,  C07C51/36

CPC分类号： C07F9/653 ,  B01J31/189 ,  B01J2231/645 ,  B01J2531/827 ,  C07B2200/07 ,  C07C51/36 ,  C07F15/0033 ,  C07F15/0046 ,  C07C59/68 ,  C07C57/30

摘要： The present invention belongs to a spiro phosphine-oxazoline and preparation method and application thereof, particularly, publishes a novel spiro phosphine-oxazoline and the preparation method of its iridium complex. The substituted 7-diaryl phosphino-7′-carboxy-1,1′-Lo-dihydro-indene is used as the starting raw material to synthesize the novel spiro phosphine-oxazoline of the present invention through a two-step reaction. The novel spiro phosphine-oxazoline and the iridium precursor are complexed to become a complex, and then through ion exchange, an iridium/phosphine spiro-oxazoline complex with different anions can be obtained. The present invention overcomes the shortcomings of the existing technology. The cheap readily available amino alcohol is used as the raw material to synthesize the novel spiro phosphine-oxazoline, on the fourth position of the oxazoline ring of which there is no substitutent. The iridium complex of this novel spiro phosphine-oxazoline can catalyze the asymmetric hydrogenation of α-substituted acrylic acid, and shows very high activity and enantioselectivity, therefore has a very high research value and an industrialization prospect.

摘要翻译： 本发明属于螺膦 - 恶唑啉及其制备方法和应用，特别是出版了一种新型的辛基膦恶唑啉及其铱络合物的制备方法。 使用取代的7-二芳基膦基-7'-羧基-1,1'-二氢 - 茚作为起始原料，通过两步反应合成本发明的新型螺膦 - 恶唑啉。 新型螺膦 - 恶唑啉和铱前体络合成为络合物，然后通过离子交换，可以获得具有不同阴离子的铱/膦螺恶唑啉络合物。 本发明克服了现有技术的缺点。 在不具有取代基的恶唑啉环的第四位上，使用便宜的氨基醇作为合成新型螺膦 - 恶唑啉的原料。 该新型螺膦 - 恶唑啉的铱络合物可以催化α-取代的丙烯酸的不对称氢化，显示出非常高的活性和对映选择性，具有很高的研究价值和工业化前景。