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    Method for preparing atosiban acetate
    1.
    发明授权
    Method for preparing atosiban acetate 有权
    阿托品醋酸酯的制备方法

    公开(公告)号：US09434767B2

    公开(公告)日：2016-09-06

    申请号：US13579030

    申请日：2011-12-22

    申请人： Qing Xiao ,  Jian Liu ,  Hongling Li ,  Yaping Ma ,  Jiancheng Yuan

    发明人： Qing Xiao ,  Jian Liu ,  Hongling Li ,  Yaping Ma ,  Jiancheng Yuan

    IPC分类号： C07K7/64 ,  C07K7/16

    CPC分类号： C07K7/64 ,  C07K7/16

    摘要： The present invention provides a method for preparing atosiban acetate. The method comprises the following steps of: synthesizing to obtain linear atosiban; dissolving the linear atosiban in an acetonitrile aqueous solution, adjusting the pH value with ammonia water, adding H2O2 for oxidizing, filtering, purifying, and transferring salt to obtain the atosiban acetate. In the present invention, an appropriate route is provided, the linear atosiban is synthesized by adopting a solid phase method, and the atosiban is obtained by liquid phase oxidation. The method has the advantages of capabilities of solving the problem of insolubility of the linear atosiban, reducing the reaction size to the maximum extent and shortening reaction time, and being high in yield and easy to industrialize.

    摘要翻译： 本发明提供了一种制备醋酸托西班醋酸酯的方法。 该方法包括以下步骤：合成得到线性阿托西班; 将线性阿托西班溶解在乙腈水溶液中，用氨水调节pH值，加入H 2 O 2进行氧化，过滤，纯化和转移盐，得到醋酸阿托品。 在本发明中，提供了适当的途径，通过采用固相法合成线性阿托西班，通过液相氧化获得阿托西班。 该方法具有解决线性阿托西班不溶性问题的能力，最大限度地减少反应尺寸，缩短反应时间，产率高，易于工业化的优点。

    METHOD FOR PREPARING ATOSIBAN ACETATE
    2.
    发明申请
    METHOD FOR PREPARING ATOSIBAN ACETATE 有权
    制备阿托品酸酯的方法

    公开(公告)号：US20130261285A1

    公开(公告)日：2013-10-03

    申请号：US13579030

    申请日：2011-12-22

    申请人： Qing Xiao ,  Jian Liu ,  Hongling Li ,  Yaping Ma ,  Jiancheng Yuan

    发明人： Qing Xiao ,  Jian Liu ,  Hongling Li ,  Yaping Ma ,  Jiancheng Yuan

    IPC分类号： C07K7/64

    CPC分类号： C07K7/64 ,  C07K7/16

    摘要： The present invention provides a method for preparing atosiban acetate. The method comprises the following steps of: synthesizing to obtain linear atosiban; dissolving the linear atosiban in an acetonitrile aqueous solution, adjusting the pH value with ammonia water, adding H2O2 for oxidizing, filtering, purifying, and transferring salt to obtain the atosiban acetate. In the present invention, an appropriate route is provided, the linear atosiban is synthesized by adopting a solid phase method, and the atosiban is obtained by liquid phase oxidation. The method has the advantages of capabilities of solving the problem of insolubility of the linear atosiban, reducing the reaction size to the maximum extent and shortening reaction time, and being high in yield and easy to industrialize.

    摘要翻译： 本发明提供了一种制备醋酸托西班醋酸酯的方法。 该方法包括以下步骤：合成得到线性阿托西班; 将线性阿托西班溶解在乙腈水溶液中，用氨水调节pH值，加入H 2 O 2进行氧化，过滤，纯化和转移盐，得到醋酸阿托品。 在本发明中，提供了适当的途径，通过采用固相法合成线性阿托西班，通过液相氧化获得阿托西班。 该方法具有解决线性阿托西班不溶性问题的能力，最大限度地减少反应尺寸，缩短反应时间，产率高，易于工业化的优点。

    Sandal strap reinforcement
    4.
    发明授权
    Sandal strap reinforcement 有权

    公开(公告)号：US10588376B1

    公开(公告)日：2020-03-17

    申请号：US14999827

    申请日：2016-07-03

    申请人： Hongling Li ,  David K. Smith

    发明人： Hongling Li ,  David K. Smith

    IPC分类号： A43B3/12 ,  A43B13/12

    摘要： A sandal strap reinforcement apparatus which is incorporated into a sandal having a multi-hardness midsole to reinforce the opening around the straps. The apparatus may be made of a molded material, fabric, tape, an o-ring, cord, or the same material as the harder layer. The apparatus is molded into the midsole and serves to protect the hole or slot from damage from a strap inserted through the hole or slot.