公开(公告)号：US06275731B1

公开(公告)日：2001-08-14

申请号：US09474193

申请日：1999-12-29

申请人： Qingsheng Zhu ,  Jungkuk Kim ,  Arthur Olive ,  Jan-Pieter Heemels

发明人： Qingsheng Zhu ,  Jungkuk Kim ,  Arthur Olive ,  Jan-Pieter Heemels

IPC分类号： A61N1365

CPC分类号： A61N1/3712

摘要： A method for reducing the affects of intrinsic detection latency in a cardiac rhythm management device, wherein said method is initiated immediately prior to delivering a stimulation pulse to the heart tissue. A coincidence of intrinsic and cardiac rhythm management initiated stimulus or the delivery of a stimulation pulse proximate the time of an intrinsic event due to intrinsic detection latency may results in delivery of unnecessary backup stimulus and/or imprecise determination of a pacing threshold. When stimulating the heart, the timing sequence for delivering a stimulation pulse typically depends upon the timing of a previous intrinsic or device initiated event. Further, the method of the present invention reduces the affects of intrinsic detection latency thereby facilitating improved detection of capture and determination of capture threshold for minimizing power consumption while assuring therapeutic efficacy.

摘要翻译： 一种减轻心律管理装置中内在检测延迟的影响的方法，其中所述方法在将刺激脉冲传递到心脏组织之前立即开始。 由于内在的检测潜伏期，固有和心律管理发起的刺激或接近内在事件时间的刺激脉冲的传递的巧合可能导致递送不必要的备份刺激和/或不精确地确定起搏阈值。 当刺激心脏时，用于递送刺激脉冲的定时序列通常取决于先前的固有或设备启动事件的时序。 此外，本发明的方法减少了内在检测潜能的影响，从而有助于提高捕获捕获阈值的检测和捕获阈值的确定，以最大限度地降低功耗，同时确保治疗效果。

公开(公告)号：US6038474A

公开(公告)日：2000-03-14

申请号：US260943

申请日：1999-03-02

申请人： Qingsheng Zhu ,  Jungkuk Kim ,  Arthur Olive ,  Jan-Pieter Heemels

发明人： Qingsheng Zhu ,  Jungkuk Kim ,  Arthur Olive ,  Jan-Pieter Heemels

IPC分类号： A61N1/37 ,  A61N1/365

CPC分类号： A61N1/3712

摘要： A method for reducing the affects of intrinsic detection latency in a cardiac rhythm management device, wherein said method is initiated immediately prior to delivering a stimulation pulse to the heart tissue. A coincidence of intrinsic and cardiac rhythm management initiated stimulus or the delivery of a stimulation pulse proximate the time of an intrinsic event due to intrinsic detection latency may results in delivery of unnecessary backup stimulus and/or imprecise determination of a pacing threshold. When stimulating the heart, the timing sequence for delivering a stimulation pulse typically depends upon the timing of a previous intrinsic or device initiated event. Further, the method of the present invention reduces the affects of intrinsic detection latency thereby facilitating improved detection of capture and determination of capture threshold for minimizing power consumption while assuring therapeutic efficacy.

摘要翻译： 一种减轻心律管理装置中内在检测延迟的影响的方法，其中所述方法在将刺激脉冲传递到心脏组织之前立即开始。 由于内在的检测潜伏期，固有和心律管理发起的刺激或接近内在事件时间的刺激脉冲的传递的巧合可能导致递送不必要的备份刺激和/或不精确地确定起搏阈值。 当刺激心脏时，用于递送刺激脉冲的定时序列通常取决于先前的固有或设备启动事件的时序。 此外，本发明的方法减少了内在检测潜能的影响，从而有助于提高捕获捕获阈值的检测和捕获阈值的确定，以最大限度地降低功耗，同时确保治疗效果。

公开(公告)号：US20090187228A1

公开(公告)日：2009-07-23

申请号：US12415660

申请日：2009-03-31

申请人： Geng Zhang ,  Jungkuk Kim ,  Qingsheng Zhu

发明人： Geng Zhang ,  Jungkuk Kim ,  Qingsheng Zhu

IPC分类号： A61N1/362

CPC分类号： A61N1/3712 ,  A61N1/3716

摘要： A cardiac electrical stimulation system that enhances the ability of the system to automatically detect whether an electrical stimulus results in heart capture or contraction. The cardiac electrical stimulation system may be utilized, for example, as a cardiac pacer or as a cardioverter defibrillator. The cardiac electrical stimulation system includes an electrical stimulation circuit that attenuates polarization voltages or “afterpotential” which develop at the heart tissue/electrode interface following the delivery of a stimulus to the heart tissue, which thereby allows the stimulation electrodes to be utilized to sense an evoked response to the electrical stimulus. The cardiac electrical stimulation system utilizes the stimulation electrodes to sense an evoked response, thereby eliminating the necessity for an indifferent electrode to sense an evoked response. The present invention allows accurate detection of an evoked response of the heart, to thereby determine whether each electrical stimulus results in capture.

摘要翻译： 心脏电刺激系统，其增强系统自动检测电刺激是否导致心脏捕获或收缩的能力。 心脏电刺激系统可以用作例如心脏起搏器或心律转复除颤器。 心脏电刺激系统包括电刺激电路，该电刺激电路衰减在向心脏组织递送刺激之后在心脏组织/电极界面处发展的极化电压或“后电位”，从而允许刺激电极用于感测 诱发对电刺激的反应。 心脏电刺激系统利用刺激电极来感测诱发反应，从而消除无关电极感应诱发反应的必要性。 本发明允许精确检测心脏的诱发反应，从而确定每个电刺激是否导致捕获。

公开(公告)号：US07512441B2

公开(公告)日：2009-03-31

申请号：US09753738

申请日：2001-01-02

申请人： Geng Zhang ,  Jungkuk Kim ,  Qingsheng Zhu

发明人： Geng Zhang ,  Jungkuk Kim ,  Qingsheng Zhu

IPC分类号： A61N1/368

CPC分类号： A61N1/3712 ,  A61N1/3716

摘要： A cardiac electrical stimulation system that enhances the ability of the system to automatically detect whether an electrical stimulus results in heart capture or contraction. The cardiac electrical stimulation system may be utilized, for example, as a cardiac pacer or as a cardioverter defibrillator. The cardiac electrical stimulation system includes an electrical stimulation circuit that attenuates polarization voltages or “afterpotential” which develop at the heart tissue/electrode interface following the delivery of a stimulus to the heart tissue, which thereby allows the stimulation electrodes to be utilized to sense an evoked response to the electrical stimulus. The cardiac electrical stimulation system utilizes the stimulation electrodes to sense an evoked response, thereby eliminating the necessity for an indifferent electrode to sense an evoked response. The present invention allows accurate detection of an evoked response of the heart, to thereby determine whether each electrical stimulus results in capture.

摘要翻译： 心脏电刺激系统，其增强系统自动检测电刺激是否导致心脏捕获或收缩的能力。 心脏电刺激系统可以用作例如心脏起搏器或心律转复除颤器。 心脏电刺激系统包括电刺激电路，该电刺激电路衰减在向心脏组织递送刺激之后在心脏组织/电极界面处产生的极化电压或“后电位”，从而允许刺激电极用于感测 诱发对电刺激的反应。 心脏电刺激系统利用刺激电极来感测诱发反应，从而消除无关电极感应诱发反应的必要性。 本发明允许精确检测心脏的诱发反应，从而确定每个电刺激是否导致捕获。

公开(公告)号：US07092756B2

公开(公告)日：2006-08-15

申请号：US09206329

申请日：1998-12-08

申请人： Geng Zhang ,  Jungkuk Kim ,  Qingsheng Zhu

发明人： Geng Zhang ,  Jungkuk Kim ,  Qingsheng Zhu

IPC分类号： A61N1/362

CPC分类号： A61N1/3704 ,  A61N1/3716

摘要： A cardiac pacing system that enhances the ability of a cardiac pacer to automatically detect whether a pacing stimulus results in heart capture or contraction. The cardiac pacing system includes a pacing circuit that attenuates polarization voltages or “afterpotential” which develop at the heart tissue/electrode interface following the delivery of a stimulus to the heart tissue, which thereby allows the pacing electrodes to be utilized to sense an evoked response to the pacing stimulus. The cardiac pacing system utilizes the pacing electrodes to sense an evoked response, thereby eliminating the necessity for an indifferent electrode to sense an evoked response. The present invention allows accurate detection of an evoked response of the heart, to thereby determine whether each pacing stimulus results in capture.

摘要翻译： 心脏起搏系统，其增强心脏起搏器自动检测起搏刺激是否导致心脏捕获或收缩的能力。 心脏起搏系统包括一个起搏电路，该起搏电路在脉冲递送到心脏组织之后衰减极化电压或在心脏组织/电极界面处产生的“后电位”，从而允许使用起搏电极感测诱发反应 到起搏刺激。 心脏起搏系统利用起搏电极来感测诱发反应，从而消除无关电极感应诱发反应的必要性。 本发明允许准确检测心脏的诱发反应，从而确定每个起搏刺激是否导致捕获。

公开(公告)号：US08224446B2

公开(公告)日：2012-07-17

申请号：US12415660

申请日：2009-03-31

申请人： Geng Zhang ,  Jungkuk Kim ,  Qingsheng Zhu

发明人： Geng Zhang ,  Jungkuk Kim ,  Qingsheng Zhu

IPC分类号： A61N1/362

CPC分类号： A61N1/3712 ,  A61N1/3716

摘要： A cardiac electrical stimulation system that enhances the ability of the system to automatically detect whether an electrical stimulus results in heart capture or contraction. The cardiac electrical stimulation system may be utilized, for example, as a cardiac pacer or as a cardioverter defibrillator. The cardiac electrical stimulation system includes an electrical stimulation circuit that attenuates polarization voltages or “afterpotential” which develop at the heart tissue/electrode interface following the delivery of a stimulus to the heart tissue, which thereby allows the stimulation electrodes to be utilized to sense an evoked response to the electrical stimulus. The cardiac electrical stimulation system utilizes the stimulation electrodes to sense an evoked response, thereby eliminating the necessity for an indifferent electrode to sense an evoked response. The present invention allows accurate detection of an evoked response of the heart, to thereby determine whether each electrical stimulus results in capture.

摘要翻译： 心脏电刺激系统，其增强系统自动检测电刺激是否导致心脏捕获或收缩的能力。 心脏电刺激系统可以用作例如心脏起搏器或心律转复除颤器。 心脏电刺激系统包括电刺激电路，该电刺激电路衰减在向心脏组织递送刺激之后在心脏组织/电极界面处发展的极化电压或“后电位”，从而允许刺激电极用于感测 诱发对电刺激的反应。 心脏电刺激系统利用刺激电极来感测诱发反应，从而消除无关电极感应诱发反应的必要性。 本发明允许精确检测心脏的诱发反应，从而确定每个电刺激是否导致捕获。

公开(公告)号：US6029086A

公开(公告)日：2000-02-22

申请号：US94773

申请日：1998-06-15

申请人： Jungkuk Kim ,  Jesse W. Hartley ,  Qingsheng Zhu

发明人： Jungkuk Kim ,  Jesse W. Hartley ,  Qingsheng Zhu

IPC分类号： A61N1/362 ,  A61N1/365 ,  A61N1/368

CPC分类号： A61N1/3704 ,  A61N1/365 ,  A61N1/368

摘要： An implantable cardiac rhythm management device includes a controller adapted to receive digitized electrocardiogram signals from leads placed on or in the heart. The device also incorporates an autosense algorithm which automatically adjusts the sensing threshold dependent upon an average or maximum amplitude of noise detected during a period following a sensed cardiac depolarization. The sensing threshold is automatically set on a beat-to-beat basis at a level such that the signal to noise ratio exceeds a preset value.

摘要翻译： 可植入心律管理装置包括适于从放置在心脏上或心脏上的引线接收数字化心电图信号的控制器。 该装置还包括自动检测算法，该算法根据在感测到的心脏去极化之后的一段时间内检测到的噪声的平均或最大振幅来自动调节感测阈值。 感测阈值以节拍为基础自动设置在使得信噪比超过预设值的水平。

公开(公告)号：US5755738A

公开(公告)日：1998-05-26

申请号：US840994

申请日：1997-04-22

申请人： Jungkuk Kim ,  Qingsheng Zhu

发明人： Jungkuk Kim ,  Qingsheng Zhu

IPC分类号： A61N1/37 ,  A61N1/365

CPC分类号： A61N1/3704

摘要： An implantable cardiac rhythm management device 10 includes a microprocessor-based controller 28 adapted to receive digitized electrogram signals from leads 14 placed on or in the heart and incorporates an autosense algorithm which is called into play when an electrogram is detected that exceeds an event detect threshold ET and capable of adjusting a sensing threshold ST to improve detection of cardiac depolarization signals in the presence of noise. The sensing threshold is automatically set on a beat-to-beat basis at a level that is dependent on a predetermined percentage of the peak amplitude of a current and an immediately preceding sensed or paced beat. The event threshold ET, which is always set at 50% of the sensing threshold, provides noise discrimination. The predetermined percentage value applied to the average peak value in arriving at the sensing threshold ST is dependent upon relative amplitudes of electrogram excursions and the signal-to-noise ratio encountered.

摘要翻译： 植入式心律管理装置10包括基于微处理器的控制器28，其适于从放置在心脏上或心脏上的引线14接收数字化的电描记图信号，并且包括自动识别算法，当检测到超过事件检测阈值的电描记图时被称为播放 ET并且能够调整感测阈值ST以改善在存在噪声的情况下的心脏去极化信号的检测。 感测阈值以取决于当前和紧前的感测或起搏节拍的峰值幅度的预定百分比的水平自动地以节拍为基础设置。 始终设置在感测阈值的50％的事件阈值ET提供噪声鉴别。 在达到感测阈值ST时应用于平均峰值的预定百分比值取决于电描记偏移的相对幅度和所遇到的信噪比。