公开(公告)号：US20240262851A1

公开(公告)日：2024-08-08

申请号：US18338750

申请日：2023-06-21

申请人： Quantum-Si Incorporated

发明人： David N. Kamber ,  Haidong Huang ,  Andrzej Wilczynski ,  Saketh Gudipati

IPC分类号： C07F9/24 ,  C07C233/60 ,  C07C271/16 ,  C07F9/6571

CPC分类号： C07F9/2408 ,  C07C233/60 ,  C07C271/16 ,  C07F9/657154 ,  C07C2601/02

摘要： Provided herein are cyclopropene phosphoramidites, which can be coupled to oligonucleotides to form cyclopropene-functionalized oligonucleotides. Also provided herein are methods of preparing cyclopropene phosphoramidites. Further provided herein are methods of functionalizing oligonucleotides by reaction with tetrazines, providing oligonucleotide cycloadduct products.

公开(公告)号：US20240151729A1

公开(公告)日：2024-05-09

申请号：US18491693

申请日：2023-10-20

申请人： Quantum-Si Incorporated

发明人： Haidong Huang ,  Saketh Gudipati ,  Roger R. Nani

IPC分类号： G01N33/58 ,  G01N33/68

CPC分类号： G01N33/582 ,  G01N33/6803

摘要： Provided herein are luminescently labeled oligonucleotide structures, which may be used in systems and methods for polypeptide sequencing and/or nucleic acid sequencing.