公开(公告)号：US11053542B2

公开(公告)日：2021-07-06

申请号：US16067189

申请日：2016-12-30

Applicant: Quest Diagnostics Investments LLC

Inventor： Shih-Min Cheng ,  Joseph J. Catanese ,  Andrew Grupe ,  Feras Hantash ,  Frederic M. Waldman ,  Kevin Qu

IPC: C12Q1/6874 ,  C12Q1/6886 ,  C12Q1/6869 ,  C12N15/10

Abstract: The present technology relates to methods for determining whether a patient having thyroid nodules with indeterminate cytology will benefit from diagnostic surgery, e.g., lobectomy. These methods are based on screening a patient's thyroid nodules and detecting alterations in target nucleic acid sequences corresponding to a specific set of thyroid cancer-related genes. Kits for use in practicing the methods are also provided.