公开(公告)号：US11993820B2

公开(公告)日：2024-05-28

申请号：US17234297

申请日：2021-04-19

Applicant: Quest Diagnostics Investments LLC

Inventor： Kevin Qu ,  Feras Hantash ,  Amber Donahue

IPC: C12Q1/6886 ,  C07K14/82 ,  C12N9/16 ,  C12Q1/6816 ,  C12Q1/6827

CPC classification number: C12Q1/6886 ,  C07K14/82 ,  C12N9/16 ,  C12Q1/6816 ,  C12Q1/6827 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/16

Abstract: The present technology relates to methods for excluding Lynch syndrome as a possible diagnosis in patients suffering from colorectal cancers or endometrial cancers. These methods are based on detecting the methylation status of the MLH1 promoter ‘C’ region in colorectal and endometrial cancer patients using an improved and highly sensitive methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) assay.

公开(公告)号：US11959143B2

公开(公告)日：2024-04-16

申请号：US17103544

申请日：2020-11-24

Applicant: Quest Diagnostics Investments LLC

Inventor： Kevin Qu ,  Anthony Sferruzza ,  Ke Zhang ,  Yan Liu ,  Renius Owen

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.

公开(公告)号：US20190062844A1

公开(公告)日：2019-02-28

申请号：US15999033

申请日：2018-08-20

Applicant: Quest Diagnostics Investments LLC

Inventor： Kevin Qu ,  Anthony Sferruzza ,  Ke Zhang ,  Yan Liu ,  Renius Owen

IPC: C12Q1/6886

Abstract: Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.

公开(公告)号：US20240301508A1

公开(公告)日：2024-09-12

申请号：US18674280

申请日：2024-05-24

Applicant: Quest Diagnostics Investments LLC

Inventor： Kevin Qu ,  Feras Hantash ,  Amber Donahue

IPC: C12Q1/6886 ,  C07K14/82 ,  C12N9/16 ,  C12Q1/6816 ,  C12Q1/6827

CPC classification number: C12Q1/6886 ,  C07K14/82 ,  C12N9/16 ,  C12Q1/6816 ,  C12Q1/6827 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/16

Abstract: The present technology relates to methods for excluding Lynch syndrome as a possible diagnosis in patients suffering from colorectal cancers or endometrial cancers. These methods are based on detecting the methylation status of the MLH1 promoter ‘C’ region in colorectal and endometrial cancer patients using an improved and highly sensitive methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) assay.

公开(公告)号：US11981966B2

公开(公告)日：2024-05-14

申请号：US16870033

申请日：2020-05-08

Applicant: Quest Diagnostics Investments LLC

Inventor： Heather Sanders ,  Kevin Qu ,  James Prentice ,  Frederic Waldman

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/16

Abstract: The present technology relates to methods for determining whether a patient diagnosed with breast cancer, colorectal cancer, melanoma or lung cancer will benefit from or is predicted to be responsive to treatment with an individual therapeutic agent or a specific combination of therapeutic agents. These methods are based on screening a patient's solid tumors and detecting alterations in target nucleic acid sequences corresponding to a specific set of cancer-related genes. Kits for use in practicing the methods are also provided.

公开(公告)号：US10982288B2

公开(公告)日：2021-04-20

申请号：US16324365

申请日：2017-08-09

Applicant: Quest Diagnostics Investments LLC

Inventor： Kevin Qu ,  Feras Hantash ,  Amber Donahue

IPC: C12Q1/6886 ,  C12N9/16 ,  C07K14/82 ,  C12Q1/6816 ,  C12Q1/6827

Abstract: The present technology relates to methods for excluding Lynch syndrome as a possible diagnosis in patients suffering from colorectal cancers or endometrial cancers. These methods are based on detecting the methylation status of the MLH1 promoter ‘C’ region in colorectal and endometrial cancer patients using an improved and highly sensitive methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) assay.

公开(公告)号：US20230058588A1

公开(公告)日：2023-02-23

申请号：US17892804

申请日：2022-08-22

Applicant: Quest Diagnostics Investments LLC

Inventor： Kevin Qu ,  Ke Zhang ,  Maher Albitar

IPC: C12Q1/6886 ,  G01N33/574

Abstract: Provided herein are methods for the diagnosis, or management of liver diseases, e.g.. hepatocellular carcinoma, using profiles of the miRNAs determined from cellular or acellular body fluids.

公开(公告)号：US11421283B2

公开(公告)日：2022-08-23

申请号：US16577491

申请日：2019-09-20

Applicant: Quest Diagnostics Investments LLC

Inventor： Kevin Qu ,  Ke Zhang ,  Maher Albitar

IPC: C12Q1/6886 ,  G01N33/574

Abstract: Provided herein are methods for the diagnosis, or management of liver diseases, e.g., hepatocellular carcinoma, using profiles of the miRNAs determined from cellular or acellular body fluids.

公开(公告)号：US20210254172A1

公开(公告)日：2021-08-19

申请号：US17234297

申请日：2021-04-19

Applicant: Quest Diagnostics Investments LLC

Inventor： Kevin Qu ,  Feras Hantash ,  Amber Donahue

IPC: C12Q1/6886 ,  C12N9/16 ,  C07K14/82 ,  C12Q1/6816 ,  C12Q1/6827

Abstract: The present technology relates to methods for excluding Lynch syndrome as a possible diagnosis in patients suffering from colorectal cancers or endometrial cancers. These methods are based on detecting the methylation status of the MLH1 promoter ‘C’ region in colorectal and endometrial cancer patients using an improved and highly sensitive methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) assay.

公开(公告)号：US11053542B2

公开(公告)日：2021-07-06

申请号：US16067189

申请日：2016-12-30

Applicant: Quest Diagnostics Investments LLC

Inventor： Shih-Min Cheng ,  Joseph J. Catanese ,  Andrew Grupe ,  Feras Hantash ,  Frederic M. Waldman ,  Kevin Qu

IPC: C12Q1/6874 ,  C12Q1/6886 ,  C12Q1/6869 ,  C12N15/10

Abstract: The present technology relates to methods for determining whether a patient having thyroid nodules with indeterminate cytology will benefit from diagnostic surgery, e.g., lobectomy. These methods are based on screening a patient's thyroid nodules and detecting alterations in target nucleic acid sequences corresponding to a specific set of thyroid cancer-related genes. Kits for use in practicing the methods are also provided.