公开(公告)号：US20130345435A1

公开(公告)日：2013-12-26

申请号：US14000170

申请日：2012-01-12

申请人： Qunzhen Guo ,  Gouping Cai ,  Tangjun Wang ,  Jiandi Yu ,  Wei Liu

发明人： Qunzhen Guo ,  Gouping Cai ,  Tangjun Wang ,  Jiandi Yu ,  Wei Liu

IPC分类号： C07D249/12

CPC分类号： C07D249/12

摘要： A preparation method of carfentrazone-ethyl comprises steps of: reacting 1-(5-amino-4-chloro-2-fluorophenyl)-4-difluoromethyl-3-methyl-1H-1,2,4-triazol-5-one with acrylic acid through a diazo arylation reaction to give 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,3-triazol-1-yl]-4-fluorophenyl}propionic acid; and reacting the 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,3-triazol-1-yl]-4-fluorophenyl}propionic acid with ethanol through an esterification reaction in a presence of an acidic catalyst to give carfentrazone-ethyl.