公开(公告)号：US20130345435A1

公开(公告)日：2013-12-26

申请号：US14000170

申请日：2012-01-12

申请人： Qunzhen Guo ,  Gouping Cai ,  Tangjun Wang ,  Jiandi Yu ,  Wei Liu

发明人： Qunzhen Guo ,  Gouping Cai ,  Tangjun Wang ,  Jiandi Yu ,  Wei Liu

IPC分类号： C07D249/12

CPC分类号： C07D249/12

摘要： A preparation method of carfentrazone-ethyl comprises steps of: reacting 1-(5-amino-4-chloro-2-fluorophenyl)-4-difluoromethyl-3-methyl-1H-1,2,4-triazol-5-one with acrylic acid through a diazo arylation reaction to give 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,3-triazol-1-yl]-4-fluorophenyl}propionic acid; and reacting the 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,3-triazol-1-yl]-4-fluorophenyl}propionic acid with ethanol through an esterification reaction in a presence of an acidic catalyst to give carfentrazone-ethyl.

公开(公告)号：US08957220B2

公开(公告)日：2015-02-17

申请号：US14000170

申请日：2012-01-12

申请人： Qunzhen Guo ,  Guoping Cai ,  Tangjun Wang ,  Jiandi Yu ,  Wei Liu

发明人： Qunzhen Guo ,  Guoping Cai ,  Tangjun Wang ,  Jiandi Yu ,  Wei Liu

IPC分类号： C07D249/04 ,  C07D249/12

CPC分类号： C07D249/12

摘要： A preparation method of carfentrazone-ethyl comprises steps of: reacting 1-(5-amino-4-chloro-2-fluorophenyl)-4-difluoromethyl-3-methyl-1H-1,2,4-triazol-5-one with acrylic acid through a diazo arylation reaction to give 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,3-triazol-1-yl]-4-fluorophenyl}propionic acid; and reacting the 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,3-triazol-1-yl]-4-fluorophenyl}propionic acid with ethanol through an esterification reaction in a presence of an acidic catalyst to give carfentrazone-ethyl.

摘要翻译： 氟哌唑酮的制备方法包括以下步骤：使1-（5-氨基-4-氯-2-氟苯基）-4-二氟甲基-3-甲基-1H-1,2,4-三唑-5-酮与 通过重氮芳基化反应得到2-氯-3- {2-氯-5- [4-（二氟甲基）-4,5-二氢-3-甲基-5-氧代-1H-1,2,3 - 三唑-1-基] -4-氟苯基}丙酸; 并使2-氯-3- {2-氯-5- [4-（二氟甲基）-4,5-二氢-3-甲基-5-氧代-1H-1,2,3-三唑-1-基 ] -4-氟苯基}丙酸与乙醇通过酯化反应在酸性催化剂的存在下反应，得到氟酮唑酮。