公开(公告)号：US06205353B1

公开(公告)日：2001-03-20

申请号：US09218199

申请日：1998-12-22

申请人： R. R. Alfano ,  Wei Cai ,  Melvin Lax

发明人： R. R. Alfano ,  Wei Cai ,  Melvin Lax

IPC分类号： A61B505

CPC分类号： A61B5/0091 ,  A61B5/0073 ,  A61B5/4312 ,  A61B5/7257 ,  G01N21/4795

摘要： A method for imaging objects in a highly scattering turbid medium, such as breast, brain, prostate in human body and clouds, smoke in atmosphere environment, using backscattered light. The method involves using a group of sources and detectors setting on same side of medium to generate a plurality of time-resolved intensity data of backscattered light from the medium. The inverse computation using a reconstruction algorithm, taking the measured data as input, produces a three-dimensional image map of the internal structure of a turbid medium. The invention teaches (1) developing an accurate analytical solution of the Boltzmann photon transport equation in a uniform infinite medium, and its extension to the case of a semi-infinite medium, which serves as a background Green's function for the forward model; (2) building a forward physical model of relationship between measurement of backscattered light and inhomogeneity structure of the medium; (3) designing an inverse algorithm for backscattering tomography; (4) designing experimental setups for breast tumor detection using backscattering tomography; (5) using fsec, psec, and nsec laser pulse with different wavelengths in the near infrared spectral region; and (6) using pico-second time gating system as detectors to collect time-slicing data.

摘要翻译： 用于在高度散射的混浊介质（例如人体和云中的乳腺，脑，前列腺，在大气环境中使用背散射光）中的物体成像的方法。 该方法包括使用在介质的相同侧设置的一组源和检测器来产生来自介质的多个后向散射光的时间分辨强度数据。 使用重建算法的逆计算，以测量数据为输入，产生混浊介质的内部结构的三维图像映射。 本发明教导（1）在均匀无限介质中开发玻尔兹曼光子传输方程的精确解析解，并将其扩展到半无限介质的情况，其作为前向模型的背景格林函数; （2）建立反向散射光测量与介质不均匀结构关系的前向物理模型; （3）设计反向散射断层扫描的逆算法; （4）使用后向散射层析成像设计乳房肿瘤检测实验装置; （5）在近红外光谱区域使用具有不同波长的fsec，psec和nsec激光脉冲; 和（6）使用微秒级门控系统作为检测器来收集时间分割数据。