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公开(公告)号：US20240197907A1
公开(公告)日：2024-06-20
申请号：US18268919
申请日：2022-01-13
IPC分类号： A61K47/68
CPC分类号： A61K47/6889
摘要： The present disclosure provides antibody-drug conjugate structures, where the antibody-drug conjugate includes a cleavable linker containing an ester group that links the antibody to the drug. The disclosure also encompasses compounds and methods for production of such conjugates. In addition, the disclosure also encompasses pharmaceutical compositions and methods of using the conjugates.
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公开(公告)号：US20220241423A1
公开(公告)日：2022-08-04
申请号：US17575481
申请日：2022-01-13
摘要： The present disclosure provides antibody-drug conjugate (ADC) structures, which include a camptothecine or a camptothecine derivative linked to a polypeptide (e.g., an antibody) through a linker. The disclosure also encompasses compounds and methods for production of such conjugates, as well as methods of using the conjugates.
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公开(公告)号：US20210393789A1
公开(公告)日：2021-12-23
申请号：US17287792
申请日：2019-10-23
发明人： David Rabuka , Junjie Liu , Stepan Chuprakov
摘要： The present disclosure provides antibody-drug conjugate structures, that include a cleavable linker having a sulfatase-cleavable moiety. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
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公开(公告)号：US10195283B2
公开(公告)日：2019-02-05
申请号：US15459887
申请日：2017-03-15
发明人： Stepan Chuprakov , Romas Alvydas Kudirka , Jesse M. McFarland , Albert W. Garafalo , David Rabuka
IPC分类号： C07D498/18 , A61K47/48
摘要： The present disclosure provides conjugate structures and hydrazinyl-substituted heteroaryl compounds used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates and compounds, as well as methods of using the same.
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公开(公告)号：US11980668B2
公开(公告)日：2024-05-14
申请号：US17287792
申请日：2019-10-23
CPC分类号： A61K47/6803 , A61K38/07 , A61K47/6849 , A61K47/6851 , A61K47/6889
摘要： The present disclosure provides antibody-drug conjugate structures, that include a cleavable linker having a sulfatase-cleavable moiety. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
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公开(公告)号：US20230277676A1
公开(公告)日：2023-09-07
申请号：US18087338
申请日：2022-12-22
IPC分类号： A61K47/54 , A61K47/64 , C07D471/14 , C07D491/22 , C07K5/062
CPC分类号： A61K47/545 , A61K47/64 , C07D471/14 , C07D491/22 , C07K5/06026
摘要： The present disclosure provides antibody-drug conjugate (ADC) structures, which include a camptothecine or a camptothecine derivative linked to a polypeptide (e.g., an antibody) through a linker. The disclosure also encompasses compounds and methods for production of such conjugates, as well as methods of using the conjugates.
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公开(公告)号：US10758628B2
公开(公告)日：2020-09-01
申请号：US16219398
申请日：2018-12-13
发明人： Stepan Chuprakov , Romas Alvydas Kudirka , Jesse M. McFarland , Albert W. Garafalo , David Rabuka
IPC分类号： A61K47/68 , A61K47/54 , C07D498/18
摘要： The present disclosure provides conjugate structures and hydrazinyl-substituted heteroaryl compounds used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates and compounds, as well as methods of using the same.
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公开(公告)号：US20240343818A1
公开(公告)日：2024-10-17
申请号：US18578669
申请日：2022-08-24
发明人： Stepan Chuprakov , Ayodele O. Ogunkoya , Penelope M. Drake , Yun Kim , Maxine Bauzon , Colin Hickle , Robyn M. Barfield
CPC分类号： C07K16/2878 , A61K47/549 , A61K47/68031 , A61K47/68033 , A61K47/6849 , A61P35/00 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/567
摘要： The present disclosure provides binding agents, particularly, antibodies, that comprise variable regions comprising humanized framework regions. Nucleic acids that encode one or both of the variable chains of the binding agents of the present disclosure are also provided, as are cells that include such nucleic acids. Also provided are compositions, including in some instances, pharmaceutical compositions, that include the binding agents disclosed herein. Methods of making and using the binding agents of the present disclosure are also provided. In certain aspects, provided are methods that include administering to an individual having a cell proliferative disorder a therapeutically effective amount of a binding agent disclosed herein, where the binding agent is administered to the individual to enhance an immune response, e.g., a T cell response, to abnormally proliferating cells. The binding agents are also useful in various diagnostic, and monitoring applications, which are also provided.
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公开(公告)号：US11564989B2
公开(公告)日：2023-01-31
申请号：US17575481
申请日：2022-01-13
IPC分类号： C07D471/14 , C07D491/22 , A61K47/64 , A61K47/54 , C07K5/062
摘要： The present disclosure provides antibody-drug conjugate (ADC) structures, which include a camptothecine or a camptothecine derivative linked to a polypeptide (e.g., an antibody) through a linker. The disclosure also encompasses compounds and methods for production of such conjugates, as well as methods of using the conjugates.
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公开(公告)号：US20190192680A1
公开(公告)日：2019-06-27
申请号：US16219398
申请日：2018-12-13
发明人： Stepan Chuprakov , Romas Alvydas Kudirka , Jesse M. McFarland , Albert W. Garafalo , David Rabuka
IPC分类号： A61K47/68 , C07D498/18 , A61K47/54
CPC分类号： A61K47/6803 , A61K47/545 , C07D498/18
摘要： The present disclosure provides conjugate structures and hydrazinyl-substituted heteroaryl compounds used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates and compounds, as well as methods of using the same.
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