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    PLIF MULTIMERIC PEPTIDES AND USES THEREOF
    1.
    发明申请
    PLIF MULTIMERIC PEPTIDES AND USES THEREOF 有权
    PLIF多功能肽及其用途

    公开(公告)号：US20130252905A1

    公开(公告)日：2013-09-26

    申请号：US13792102

    申请日：2013-03-10

    Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

    Inventor： Chaya MOROZ

    IPC: C07K14/00 ,  C07K7/08

    CPC classification number: A61K39/0011 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/57 ,  A61K2039/58 ,  C07K7/08 ,  C07K14/001 ,  C07K14/47 ,  C07K14/4705 ,  C07K2319/00

    Abstract: Provided is a multimeric peptide comprising at least two peptide monomers linked to one another, each of the at least two peptide monomers comprising at least 6 consecutive amino acids from the amino acid sequence as set forth in SEQ ID NO: 1, wherein the at least two peptide monomers are each no longer than 30 amino acids, wherein the multimeric peptide is capable of reducing binding of Placenta Immunomodulatory Factor (PLIF) to human leukocytes.

    Abstract translation: 提供了包含至少两个彼此连接的肽单体的多聚体肽，所述至少两种肽单体中的每一种包含SEQ ID NO：1所示的氨基酸序列至少6个连续的氨基酸，其中至少 两个肽单体各自不超过30个氨基酸，其中多聚体肽能够降低胎盘免疫调节因子（PLIF）与人白细胞的结合。

    PLIF MULTIMERIC PEPTIDES AND USES THEREOF
    2.
    发明申请
    PLIF MULTIMERIC PEPTIDES AND USES THEREOF 审中-公开

    公开(公告)号：US20190142919A1

    公开(公告)日：2019-05-16

    申请号：US16258725

    申请日：2019-01-28

    Applicant: Ramot at Tel-Aviv University Ltd.

    Inventor： Chaya MOROZ

    IPC: A61K39/00 ,  C07K7/08 ,  C07K14/47 ,  C07K14/00

    Abstract: Provided is a multimeric peptide comprising at least two peptide monomers linked to one another, each of the at least two peptide monomers comprising at least 6 consecutive amino acids from the amino acid sequence as set forth in SEQ ID NO: 1, wherein the at least two peptide monomers are each no longer than 30 amino acids, wherein the multimeric peptide is capable of reducing binding of Placenta Immunomodulatory Factor (PLIF) to human leukocytes.

    GENERATION OF CYTOTOXIC TUMOR SPECIFIC CELL LINES AND USES THEREOF
    3.
    发明申请
    GENERATION OF CYTOTOXIC TUMOR SPECIFIC CELL LINES AND USES THEREOF 审中-公开

    公开(公告)号：US20180282696A1

    公开(公告)日：2018-10-04

    申请号：US16010560

    申请日：2018-06-18

    Applicant: Ramot at Tel-Aviv University Ltd.

    Inventor： Chaya MOROZ ,  Inna SOLODEEV

    IPC: C12N5/0783 ,  A61K35/17

    Abstract: An in-vitro method of activating T cells is disclosed. The method comprises incubating T cells with pathogenic cells in the presence of a multimeric peptide comprising at least two peptide monomers linked to one another, each of the at least two peptide monomers comprising at least 6 consecutive amino acids from the amino acid sequence as set forth in SEQ ID NO: 1, wherein the at least two peptide monomers are each no longer than 30 amino acids, wherein the multimeric peptide is capable of reducing binding of PLIF to human leukocytes under conditions which allow expansion of the T cells.

    GENERATION OF CYTOTOXIC TUMOR SPECIFIC CELL LINES AND USES THEREOF
    5.
    发明申请
    GENERATION OF CYTOTOXIC TUMOR SPECIFIC CELL LINES AND USES THEREOF 有权
    细胞因子肿瘤特异性细胞系的产生及其用途

    公开(公告)号：US20160122715A1

    公开(公告)日：2016-05-05

    申请号：US14765570

    申请日：2014-02-03

    Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

    Inventor： Chaya MOROZ ,  Inna SOLODEEV

    IPC: C12N5/0783 ,  A61K35/17

    CPC classification number: C12N5/0638 ,  A61K35/17 ,  C12N2501/2302 ,  C12N2501/998 ,  C12N2502/30

    Abstract: An in-vitro method of activating T cells is disclosed. The method comprises incubating T cells with pathogenic cells in the presence of a multimeric peptide comprising at least two peptide monomers linked to one another, each of the at least two peptide monomers comprising at least 6 consecutive amino acids from the amino acid sequence as set forth in SEQ ID NO: 1, wherein the at least two peptide monomers are each no longer than 30 amino acids, wherein the multimeric peptide is capable of reducing binding of PLIF to human leukocytes under conditions which allow expansion of the T cells.

    Abstract translation: 公开了一种激活T细胞的体外方法。 该方法包括在包含至少两个彼此连接的肽单体的多聚体肽的存在下孵育T细胞与致病细胞，所述至少两种肽单体中的每一种单体包含如所阐述的氨基酸序列至少6个连续的氨基酸 在SEQ ID NO：1中，其中所述至少两种肽单体各自不超过30个氨基酸，其中所述多聚体肽能够在允许扩增T细胞的条件下降低PLIF与人白细胞的结合。

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