公开(公告)号：US11118182B2

公开(公告)日：2021-09-14

申请号：US16461941

申请日：2017-11-16

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Dan Canaani ,  Ronni Aram ,  Iris Dotan ,  Pnina Gottfried Komlosh

IPC: C07H21/04 ,  C12N15/113 ,  A61P17/02 ,  A61P35/04 ,  A61K9/127 ,  C12Q1/6886 ,  G01N33/50 ,  G01N33/52

Abstract: The invention provides modulators of human cancer and tumor metastasis in particular. More specifically the present disclosure relates to modulators of SKAI1BC, an antisense long non-coding RNA which was found to be an epigenetic suppressor of the metastasis suppressor gene KAI1/CD82, compositions, methods and uses thereof for decreasing metastasis, invasion and possibly also proliferation of cancer cells.