公开(公告)号：US12060572B2

公开(公告)日：2024-08-13

申请号：US16606240

申请日：2018-04-18

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Adi Barzel ,  Iris Dotan ,  Carmel Pundak-Mintz ,  Daniel Nataf ,  Miriam Fried ,  Natalia Gritsenko

IPC: C12N15/90 ,  C07K16/28 ,  C12N15/86

CPC classification number: C12N15/907 ,  C07K16/2809 ,  C12N15/86 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/76 ,  C12N2510/00

Abstract: The present invention relates to methods for targeted insertion of at least one nucleic acid sequence/s of interest into a target genomic locus of a mammalian cell. More specifically, the methods of the invention are based on using nucleic acid cassettes comprising the nucleic acid sequence/s of interest and at least one recognition signal sequence (RSS), for insertion of the nucleic acid sequence of interest into the target genomic locus that is mediated by RAG-catalyzed recombination. The invention further provides cassettes, vectors and vehicles and cells comprising said cassettes, compositions and uses thereof in immunotherapy.

公开(公告)号：US20240329048A1

公开(公告)日：2024-10-03

申请号：US18443832

申请日：2024-02-16

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Adi Barzel ,  Iris Dotan ,  Yuval Raviv

IPC: G01N33/574 ,  C07K14/47 ,  C07K16/30 ,  G01N33/58 ,  G01N33/68

CPC classification number: G01N33/57484 ,  C07K14/4748 ,  C07K16/30 ,  G01N33/58 ,  G01N33/6854

Abstract: High throughput methods for identifying monoclonal antibodies (mAbs) targeted to tumor antigens, using membranal B-cell receptor (BCR) screening of immortalized B-cells are provided. Methods for identification and characterization of tumor-related antigens are also provided as well as therapeutic and diagnostic uses of the newly-identified antibodies and antigens in cancer.

公开(公告)号：US11118182B2

公开(公告)日：2021-09-14

申请号：US16461941

申请日：2017-11-16

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Dan Canaani ,  Ronni Aram ,  Iris Dotan ,  Pnina Gottfried Komlosh

IPC: C07H21/04 ,  C12N15/113 ,  A61P17/02 ,  A61P35/04 ,  A61K9/127 ,  C12Q1/6886 ,  G01N33/50 ,  G01N33/52

Abstract: The invention provides modulators of human cancer and tumor metastasis in particular. More specifically the present disclosure relates to modulators of SKAI1BC, an antisense long non-coding RNA which was found to be an epigenetic suppressor of the metastasis suppressor gene KAI1/CD82, compositions, methods and uses thereof for decreasing metastasis, invasion and possibly also proliferation of cancer cells.