公开(公告)号：US20240009177A1

公开(公告)日：2024-01-11

申请号：US18245970

申请日：2021-09-19

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Dor ZAGURI ,  Topaz KREISER-SHEM-TOV ,  Ehud GAZIT ,  Daniel SEGAL ,  Josef MOGRABI ,  Eran BACHARACH

IPC: A61K31/4375 ,  A61K31/352 ,  A61K33/34 ,  A61K31/315 ,  A61P31/16

CPC classification number: A61K31/4375 ,  A61K31/352 ,  A61K33/34 ,  A61K31/315 ,  A61P31/16

Abstract: Combination compositions exhibiting anti-viral activities are provided, which are based on unique combinations of polyphenol zinc ionophores. Exemplary compositions comprise combinations of flavonoid zinc ionophores selected from EGCG, quercetin and taxifolin, preferably further comprising a zinc compound and a copper compound. The compositions preferably contain additional ingredients to further enhance the anti-viral effect of the composition and/or to provide additional benefits.

公开(公告)号：US20140213627A1

公开(公告)日：2014-07-31

申请号：US14168550

申请日：2014-01-30

Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Roni SCHERZER ,  Ehud GAZIT ,  Daniel SEGAL

IPC: C07C309/14 ,  C07C211/54 ,  C07D245/04 ,  C07C229/18 ,  C07D207/09 ,  C07C229/60 ,  C07D209/14 ,  C07D209/20

CPC classification number: C07C309/14 ,  A61K31/198 ,  A61K31/255 ,  A61K31/395 ,  A61K31/405 ,  C07C211/54 ,  C07C229/18 ,  C07C229/60 ,  C07D207/09 ,  C07D209/14 ,  C07D209/20 ,  C07D245/04

Abstract: The present invention provides pharmaceutical compositions comprising substituted 1,4 naphthoquinones that are effective in preventing oligomerization of beta amyloid and subsequent pathologies associated with amyloid fibrils. These compositions are useful for the treatment of disease involving amyloidogenesis including neurodegenerative diseases such as Alzheimer's Disease or senile dementia. Particularly effective compositions comprise 1,4 naphthoquinones substituted with an amino acid residue selected from a heterocyclic or aromatic amino acid.

Abstract translation: 本发明提供了包含取代的1,4-萘醌的药物组合物，其有效预防β淀粉样蛋白的低聚和随后与淀粉样蛋白原纤维相关的病理学。 这些组合物可用于治疗包括淀粉样变性（包括神经变性疾病如阿尔茨海默病或老年痴呆）的疾病。 特别有效的组合物包含被选自杂环或芳族氨基酸的氨基酸残基取代的1,4萘醌。