公开(公告)号：US20180296551A1

公开(公告)日：2018-10-18

申请号：US15769095

申请日：2016-10-19

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Beka SOLOMON ,  Inna RABINOVICH-NIKITIN ,  Beka BARBIRO ,  Assaf EZRA

IPC: A61K31/495 ,  A61K9/00 ,  A61P25/28

Abstract: A method of treating a neurodegenerative disease is disclosed. The method comprises administering to the subject a therapeutically effective amount of a CXCR4 antagonist and lactate or/and zinc. Kits for treating same are also disclosed.

公开(公告)号：US20160206592A1

公开(公告)日：2016-07-21

申请号：US14915242

申请日：2014-08-29

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Beka SOLOMON ,  Inna RABINOVICH-NIKITIN ,  Beka BARBIRO

IPC: A61K31/395

CPC classification number: A61K31/395

Abstract: The present invention provides use of an inhibitor of G protein-coupled receptor CXCR4 for treating amyotrophic lateral sclerosis (ALS), for inhibiting glutamate release in astrocytes, or for increasing remyelinization in motor neurons.

Abstract translation: 本发明提供G蛋白偶联受体CXCR4的抑制剂用于治疗肌萎缩性侧索硬化（ALS），抑制星形胶质细胞中的谷氨酸释放或增加运动神经元的再髓鞘化的用途。