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公开(公告)号：US10351898B2
公开(公告)日：2019-07-16
申请号：US14894350
申请日：2014-01-05
发明人： Yuval Ebenstein , Micha Fridman
IPC分类号： C12Q1/6827 , C12Q1/6806 , C12P19/30 , G01N21/64
摘要： Methodologies for labeling the epigenetic modification 5-hydroxymethyl-cytosine (5hmC) along a DNA molecule, and for imaging this epigenetic modification along a DNA molecule are disclosed. Related compositions and reagents, and methods of preparing same are also disclosed.
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公开(公告)号：US20220119339A1
公开(公告)日：2022-04-21
申请号：US17452970
申请日：2021-10-29
发明人： Yoram Cohen , Micha Fridman , Roymon Joseph , Alissa Naugolny , Mark Feldman , Ido M. Herzog , Dana Kaizerman
IPC分类号： C07C217/54 , A61K31/138 , A61K31/4178 , A61K31/66 , A61K45/06 , C02F1/50 , C07D233/60 , C07F9/54 , C09D5/16
摘要： Cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives are capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition. A composition for inhibiting or disrupting biofilm, e.g., bacterial or fungal biofilm, formation, or reducing biofilm, can include a pharmaceutically acceptable carrier, and a cationic pillar[n]ene.
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公开(公告)号：US20200172471A1
公开(公告)日：2020-06-04
申请号：US15751786
申请日：2016-08-03
发明人： Yoram Cohen , Micha Fridman , Roymon Joseph , Alissa Naugolny , Mark Feldman , Ido M. Herzog , Dana Kaizerman
IPC分类号： C07C217/54 , C09D5/16 , A61K45/06 , A61K31/138 , C07D233/60 , C07F9/54 , A61K31/4178 , A61K31/66 , C02F1/50
摘要： The present invention provides cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives, capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition; as well as compositions thereof and methods of use.
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公开(公告)号：US11161801B2
公开(公告)日：2021-11-02
申请号：US15751786
申请日：2016-08-03
发明人： Yoram Cohen , Micha Fridman , Roymon Joseph , Alissa Naugolny , Mark Feldman , Ido M. Herzog , Dana Kaizerman
IPC分类号： C02F1/50 , C07C217/54 , C07D233/60 , C07F9/54 , C09D5/16 , A61K31/138 , A61K31/4178 , A61K31/66 , A61K45/06
摘要： The present invention provides cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives, capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition; as well as compositions thereof and methods of use.
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公开(公告)号：US11091793B2
公开(公告)日：2021-08-17
申请号：US16424523
申请日：2019-05-29
发明人： Yuval Ebenstein , Micha Fridman
IPC分类号： C12P19/30 , C12Q1/6806 , G01N21/64
摘要： Methodologies for labeling the epigenetic modification 5-hydroxymethylcytosine (5hmC) along a DNA molecule, and for determining a presence or a level of this epigenetic modification based on a ratio of fluorescence intensity of a labeled DNA sample to absorption intensity of the DNA sample at 260 nm are disclosed. Related compositions and reagents, and methods of preparing same are also disclosed.
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公开(公告)号：US20200072711A1
公开(公告)日：2020-03-05
申请号：US16554360
申请日：2019-08-28
IPC分类号： G01N1/30 , G01N33/569 , G01N33/58 , C09K11/06 , C09B62/343
摘要： Particular 1,2,3-triazole- and 1,2,4-triazole-based compounds can be used as fluorescent probes. The compounds can optionally be substituted with one or two fluorine atoms. The compounds are effective as specific endoplasmatic reticulum (ER)-trackers for live cell imaging in a fungal cell, such as a pathogenic yeast. Compositions including the fluorescent probes can be used in methods for tracking the endoplasmic reticulum in a fungal cell.
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