公开(公告)号：US10676511B2

公开(公告)日：2020-06-09

申请号：US15760878

申请日：2016-09-15

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Jonathan Gershoni ,  Natalia T. Freund

IPC: C07K14/005 ,  A61K39/215 ,  A61K39/12 ,  A61P31/14

Abstract: Provided are polypeptides derived from the coronaviruses (CoVs) Spike protein (S) characterized by high affinity and specificity the S receptor and its neutralizing antibodies. Further provided are compositions and vaccines, and vaccine-based therapies targeting CoVs, and SARS and MERS viruses in particular.

公开(公告)号：US11746127B2

公开(公告)日：2023-09-05

申请号：US17229100

申请日：2021-04-13

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Jonathan Gershoni ,  Natalia T. Freund

IPC: C07K14/005 ,  A61K39/215 ,  A61K39/12 ,  A61P31/14

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/215 ,  A61P31/14 ,  C07K2319/735 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20051

Abstract: The present invention provides polypeptides derived from the coronaviruses (CoVs) Spike protein (S) characterized by high affinity and specificity the S receptor and its neutralizing antibodies. The invention further provides compositions and vaccines, and vaccine-based therapies targeting CoVs, and SARS and MERS viruses in particular.