公开(公告)号：US20210361717A1

公开(公告)日：2021-11-25

申请号：US17394008

申请日：2021-08-04

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Daniel OFFEN ,  Nisim PERETS

IPC: A61K35/28 ,  A61P25/28 ,  A61P25/18 ,  A61K9/00 ,  A61K9/127

Abstract: A method of treating a neurological disease (such as autism) in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of microparticles derived from mesenchymal stem cells.

公开(公告)号：US20190209621A1

公开(公告)日：2019-07-11

申请号：US16325445

申请日：2017-08-14

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Daniel OFFEN ,  Nisim PERETS

IPC: A61K35/28 ,  A61P25/28 ,  A61P25/18 ,  A61K9/00 ,  A61K9/127

CPC classification number: A61K35/28 ,  A61K9/0043 ,  A61K9/127 ,  A61P25/18 ,  A61P25/28

Abstract: A method of treating a neurological disease (such as autism) in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of microparticles derived from mesenchymal stem cells.

公开(公告)号：US20210077520A1

公开(公告)日：2021-03-18

申请号：US17042441

申请日：2019-03-27

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Shulamit LEVENBERG ,  Shaowei GUO ,  Daniel OFFEN ,  Nisim PERETS

IPC: A61K31/713 ,  A61K35/28 ,  A61K38/51 ,  C12N15/113

Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.