公开(公告)号：US20220098598A1

公开(公告)日：2022-03-31

申请号：US17552720

申请日：2021-12-16

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Tamir TULLER ,  Hadas ZUR ,  Rachel COHEN-KUPIEC

IPC: C12N15/67 ,  C12Q1/6809 ,  C12N15/79

Abstract: Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.