公开(公告)号：US20230230658A1

公开(公告)日：2023-07-20

申请号：US18123413

申请日：2023-03-20

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Tamir TULLER ,  Hadas ZUR

IPC: G16B30/00 ,  G16B35/00 ,  G16C20/60 ,  C12N15/10 ,  G06F17/00 ,  G06F17/10 ,  G06F17/15 ,  G06F17/17

CPC classification number: G16B30/00 ,  G16B35/00 ,  G16C20/60 ,  C12N15/1089 ,  G06F17/00 ,  G06F17/10 ,  G06F17/15 ,  G06F17/17

Abstract: Methods of designing a polynucleotide sequence for expressing a polypeptide-of-interest in a cell are provided. Also provided are artificial transcript sequences generated according to the present teachings. Further provided are methods of estimating the adaptiveness of a transcript sequence encoding a polypeptide-of-interest to a gene expression machinery in a cell.

公开(公告)号：US20180273911A1

公开(公告)日：2018-09-27

申请号：US15764691

申请日：2016-09-29

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  SYNVACCINE LTD.

Inventor： Tamir TULLER ,  Eli GOZ ,  Shimshi ATAR ,  Hadas ZUR

IPC: C12N7/00 ,  A61K39/12

CPC classification number: C12N7/00 ,  A61K35/76 ,  A61K39/12 ,  A61K2039/5254 ,  C12N2770/24121 ,  C12N2770/24162 ,  G16B99/00 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/391 ,  Y02A50/465

Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.

公开(公告)号：US20250043278A1

公开(公告)日：2025-02-06

申请号：US18928324

申请日：2024-10-28

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Tamir TULLER ,  Ofek SCHNITZER ,  Hadas ZUR ,  Zohar ZAFRIR

IPC: C12N15/11 ,  C12N9/22 ,  C12N15/67 ,  C12Q1/6886

Abstract: The present invention is directed to a method for treating cancer in a subject determined as having the presence of a G600>A substitution, a C601>T substitution, or both, in the B cell lymphoma 2 (BCL2) gene of a cell.

公开(公告)号：US20220098598A1

公开(公告)日：2022-03-31

申请号：US17552720

申请日：2021-12-16

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Tamir TULLER ,  Hadas ZUR ,  Rachel COHEN-KUPIEC

IPC: C12N15/67 ,  C12Q1/6809 ,  C12N15/79

Abstract: Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.

公开(公告)号：US20220010287A1

公开(公告)日：2022-01-13

申请号：US17467265

申请日：2021-09-05

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  SYNVACCINE LTD.

Inventor： Tamir TULLER ,  Eli GOZ ,  Shimshi ATAR ,  Hadas ZUR

IPC: C12N7/00 ,  G16B99/00 ,  C12N7/04 ,  G16B15/10 ,  A61K39/12

Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.