公开(公告)号：US3812156A

公开(公告)日：1974-05-21

申请号：US19147971

申请日：1971-10-21

Applicant: RECORDATI CHEM PHARM

Inventor： BONOLA G ,  SIANESI E

IPC: C07D311/32 ,  C07D311/30 ,  C07D7/34

CPC classification number: C07D311/30

Abstract: LOWER ALKYL ESTERS OF FLAVONE-7-OXYACETIC ACID ARE MADE BY REACTING CHLOROACETONITRILE WITH RESACETOPHENONE TO GIVE 2''-HYDROXY-4''-XYANOMETHOXY ACETOPHENONE, REACTING THE LATTER COMPOUND WITH BENZOYL CHLORIDE TO GIVE 1-(2HYDROXY-4-CYANOMETHOXY PHENYL)-3-PHENYL PROPANE-1,3DIONE AND THEN REACTING THE LATTER COMPOUND WITH AN ANHYDROUS LOWER ALKANOL IN THE PRESENCE OF A MINERAL ACID.

公开(公告)号：US3795685A

公开(公告)日：1974-03-05

申请号：US3795685D

申请日：1971-07-15

Applicant: RECORDATI CHEM PHARM

Inventor： SIANESI E

IPC: C07D311/22 ,  C07C209/08 ,  C07D311/30 ,  C07D7/24

CPC classification number: C07D311/30 ,  C07C209/08

Abstract: N-ALKYL- AND N-(SUBSTITUTED ALKYL)-DIMETHYLAMINES ARE PREPARED BY REACTING AN UNSUBSTITUTED OR SUBSTITUTED ALKYL HALIDE WITH DIMETHYLAMINE IN AN AQUEOUS MEDIUM FREE FROM ORGANIC SOLVENT AND AT A TEMPERATURE NOT HIGHER THAN ABOUT 30*C.

公开(公告)号：US3770802A

公开(公告)日：1973-11-06

申请号：US3770802D

申请日：1970-11-16

Applicant: RECORDATI CHEM PHARM

Inventor： SIANESI E

IPC: C07C201/16 ,  C07C45/67 ,  C07C51/00 ,  C07C51/295 ,  C07C65/40 ,  C07C67/00 ,  C07C205/12 ,  C07D311/30 ,  C07C69/78

CPC classification number: C07D311/30 ,  C07C45/67 ,  C07C51/295 ,  C07C65/40 ,  C07C49/835

Abstract: 3-PROPIONYLSALICYLIC ACID IS MADE BY ISOMERISING 2-HYDROXY - 3 - ALLYLPROPIOPHENONE TO 2-HYDROXY-3-PROPENYLPROPIOPHENONE, OXIDIZING THE LATTER TO 3-PROPIONYLSALICYLIC ALDEHYDE AND OXIDIZING THE LATTER TO 3-PROPIONYLSALICYLIC ACID. THIS PRODUCT CAN BE CONVERTED TO LOWER ALKYL ESTERS WHICH CAN BE USED FOR THE PRODUCTION OF 3-METHYLFLAVONE-8-CARBOXYLIC ACID AND ITS ESTERS, PARTICULARLY THE AMINOALKYL ESTERS WHICH ARE THERAPEUTICALLY ACTIVE.

公开(公告)号：US3712889A

公开(公告)日：1973-01-23

申请号：US3712889D

申请日：1970-05-11

Applicant: RECORDATI CHEM PHARM

Inventor： SETNIKAR I ,  MASSARANI E ,  SIANESI E ,  DA RE P

IPC: C07C309/58 ,  C07D93/02

CPC classification number: C07C309/58

Abstract: A 3- OR 4-OXO-DIHYDROBENZOLTHIAZINE-S-DIOXIDE OF THE GENERAL FORMULA:

X
IN WHICH EITHER X OF Y STAND FOR A SINGLE BOND AND THE OTHER STANDS FOR METHYLENE (CH2) AND R REPRESENTS HYDROGEN OR ALKYL, ALKENYL, PROPARGYL, BENZYL, CARBETHOXY, DIALKYL AMINOALKYL OR CYCLOAMINOALKYL OR A GROUP OF THE FORMULA -CH2-COOR1, IN WHICH R1 REPRESENTS HYDROGEN OR ALKYL, DIALKYLAMINOALKYL OR CYCLOAMINOALKYL, OR R REPRESENTS A GROUP OF THE FORMULA:

-CH2-CO-N(-R2)(-R3)

IN WHICH R2 AND R3 ARE IDENTICAL OR DIFFERENT AND EACH REPRESENT HYDROGEN, ALKYL OR ALKENYL OR DIALKYLAMINOALKYL OR CYCLOAMINO-ALKYL GROUP OR, TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED, FORM A HETEROCYCLIC AMINO GROUP, OR R REPRESENTS AN UNSUBSTITUTED PHENYL AND OR AOR A CHLORO-SUBSTITUTED OR SULFAMYL-SUBSTITUTED PHENYL AND METHODS FOR THE PREPARATION THEREOF. THESE COMPOUNDS ARE THERAPEUTICALLY ACTIVE PARTICULARLY ON THE CENTRAL NERVOUS SYSTEM, E.G., HYPNOTIC ACTIVITY.