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    Multispecific antigen-binding molecules and uses thereof
    6.
    发明授权
    Multispecific antigen-binding molecules and uses thereof 有权

    公开(公告)号：US11129903B2

    公开(公告)日：2021-09-28

    申请号：US15202822

    申请日：2016-07-06

    Applicant: REGENERON PHARMACEUTICALS, INC.

    Inventor： Julian Andreev ,  Nithya Thambi ,  Frank Delfino ,  Joel Martin ,  Gavin Thurston ,  Katherine Cygnar ,  Nicholas Papadopoulos

    IPC: A61K47/68 ,  C07K16/22 ,  C07K16/28 ,  C07K1/32 ,  C07K16/12 ,  C07K16/18 ,  C07K14/47 ,  C07K16/30 ,  A61P35/00 ,  C07K16/46 ,  A61K39/00 ,  C12N9/64 ,  C07K16/32

    Abstract: The present invention provides multispecific antigen-binding molecules and uses thereof. The multispecific antigen-binding molecules comprise a first antigen-binding domain that specifically binds a target molecule, and a second antigen-binding domain that specifically binds an internalizing effector protein. The multispecific antigen-binding molecules of the present invention can, in some embodiments, be bispecific antibodies that are capable of binding both a target molecule and an internalizing effector protein. In certain embodiments of the invention, the simultaneous binding of the target molecule and the internalizing effector protein by the multispecific antigen-binding molecule of the present invention results in the attenuation of the activity of the target molecule to a greater extent than the binding of the target molecule alone. In other embodiments of the invention, the target molecule is a tumor associated antigen, and the simultaneous binding of the tumor associated antigen and the internalizing effector protein by the multispecific antigen-binding molecule of the present invention causes or facilitates the targeted killing of tumor cells.

    Methods of making multispecific antigen-binding molecules
    8.
    发明授权
    Methods of making multispecific antigen-binding molecules 有权

    公开(公告)号：US11352446B2

    公开(公告)日：2022-06-07

    申请号：US16097108

    申请日：2017-04-28

    Applicant: REGENERON PHARMACEUTICALS, INC.

    Inventor： Katherine Cygnar ,  Frank Delfino

    IPC: C40B30/04 ,  C07K16/46 ,  C07K16/12 ,  C07K16/28 ,  C07K16/44

    Abstract: The present invention provides multispecific antigen-binding molecules and methods of making or selecting same. The multispecific antigen-binding molecules comprise a first antigen-binding domain that specifically binds a target molecule, and a second antigen-binding domain that specifically binds an internalizing effector protein. The multispecific antigen-binding molecules of the present invention can, in some embodiments, be bispecific antibodies that are capable of binding both a target molecule and an internalizing effector protein. In certain embodiments of the invention, the simultaneous binding of the target molecule and the internalizing effector protein by the multispecific antigen-binding molecule of the present invention results in the attenuation of the activity of the target molecule to a greater extent than the binding of the target molecule alone. In other embodiments of the invention, the target molecule is a tumor associated antigen, and the simultaneous binding of the tumor associated antigen and the internalizing effector protein by the multispecific antigen-binding molecule of the present invention causes or facilitates the targeted killing of tumor cells.

    MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF
    9.
    发明申请
    MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF 有权

    公开(公告)号：US20220008548A1

    公开(公告)日：2022-01-13

    申请号：US17483588

    申请日：2021-09-23

    Applicant: Regeneron Pharmaceuticals, Inc.

    Inventor： Julian Andreev ,  Nithya Thambi ,  Frank Delfino ,  Joel Martin ,  Gavin Thurston ,  Katherine Cygnar ,  Nicholas Papadopoulos

    IPC: A61K47/68 ,  C07K16/22 ,  C07K16/28 ,  C07K16/32 ,  C12N9/64 ,  C07K16/12 ,  C07K16/18 ,  C07K14/47 ,  C07K16/30 ,  A61P35/00 ,  C07K16/46

    Abstract: The present invention provides multispecific antigen-binding molecules and uses thereof. The multispecific antigen-binding molecules comprise a first antigen-binding domain that specifically binds a target molecule, and a second antigen-binding domain that specifically binds an internalizing effector protein. The multispecific antigen-binding molecules of the present invention can, in some embodiments, be bispecific antibodies that are capable of binding both a target molecule and an internalizing effector protein. In certain embodiments of the invention, the simultaneous binding of the target molecule and the internalizing effector protein by the multispecific antigen-binding molecule of the present invention results in the attenuation of the activity of the target molecule to a greater extent than the binding of the target molecule alone. In other embodiments of the invention, the target molecule is a tumor associated antigen, and the simultaneous binding of the tumor associated antigen and the internalizing effector protein by the multispecific antigen-binding molecule of the present invention causes or facilitates the targeted killing of tumor cells.

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