公开(公告)号：US20140056907A1

公开(公告)日：2014-02-27

申请号：US14068173

申请日：2013-10-31

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： Lynn MACDONALD ,  Min GAO ,  Marc R. MORRA ,  Nicole M. ALESSANDRI-HABER ,  Michael L. LaCROIX-FRALISH

IPC: C07K16/28

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. According to certain embodiments, the antibodies of the invention are selective for ASIC1 and do not bind other acid-sensing ion channels in the absence of ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders.

Abstract translation: 本发明提供特异性结合表达酸感应离子通道-1（ASIC1）的细胞的抗体及其抗原结合片段。 根据本发明的某些实施方案，抗体在表达人ASIC1的细胞中抑制酸诱导的ASIC1介导的离子电流。 根据某些实施方案，本发明的抗体对于ASIC1是选择性的，并且在不存在ASIC1的情况下不结合其它酸感应离子通道。 本发明的抗体可用于治疗疼痛，包括与手术干预相关的疼痛以及各种疾病和病症。

公开(公告)号：US20130195878A1

公开(公告)日：2013-08-01

申请号：US13753836

申请日：2013-01-30

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Lynn MACDONALD ,  Min GAO ,  Marc R. MORRA ,  Nicole M. ALESSANDRI-HABER ,  Michael L. LaCROIX-FRALISH

IPC: C07K16/28

CPC classification number: C07K16/28 ,  A61K39/00 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders.

Abstract translation: 本发明提供特异性结合表达酸感应离子通道-1（ASIC1）的细胞的抗体及其抗原结合片段。 根据本发明的某些实施方案，抗体在表达人ASIC1的细胞中抑制酸诱导的ASIC1介导的离子电流。 本发明的抗体可用于治疗疼痛，包括与手术干预相关的疼痛以及各种疾病和病症。