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    NON-HUMAN ANIMALS THAT MAKE SINGLE DOMAIN BINDING PROTEINS
    3.
    发明申请
    NON-HUMAN ANIMALS THAT MAKE SINGLE DOMAIN BINDING PROTEINS 审中-公开
    制造单一结合蛋白质的非人类动物

    公开(公告)号：US20150289489A1

    公开(公告)日：2015-10-15

    申请号：US14664765

    申请日：2015-03-20

    Applicant: Regeneron Pharmaceuticals, Inc.

    Inventor： Lynn MACDONALD ,  Andrew J. MURPHY ,  Cagan GURER ,  John MCWHIRTER

    IPC: A01K67/027 ,  C07K16/00

    CPC classification number: A01K67/0278 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  C07K16/00 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/569 ,  C07K2317/64 ,  C12N15/8509

    Abstract: Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises (a) a deletion in an immunoglobulin constant region CH1 gene (optionally a deletion in a hinge region) of a heavy chain constant region gene sequence, and (b) replacement of one or all endogenous VH, DH and JH gene segments with at least one unrearranged light chain variable (VL) gene segment and at least one unrearranged light chain joining (JL) gene segment capable of recombining to form a rearranged light chain variable region (VL/JL) nucleotide sequence operably linked to the heavy chain constant region gene sequence comprising a deletion in the CH1 gene and/or insertion of a genetically engineered single rearranged light chain, wherein the mouse is capable of expressing a functional IgM, single domain antigen binding proteins, e.g., VL-single domain binding proteins, and a genetically engineered rearranged light chain.

    Abstract translation: 提供了遗传修饰的非人动物，以及制备和使用它们的方法和组合物，其中遗传修饰包括（a）重链恒定区的免疫球蛋白恒定区CH1基因（任选地在铰链区的缺失）中的缺失 基因序列，以及（b）用至少一个未稀释的轻链可变（VL）基因片段和至少一个能够重组的未经稀释的轻链连接（JL）基因片段替换一个或所有内源VH，DH和JH基因片段 形成与重链恒定区基因序列可操作地连接的重排轻链可变区（VL / JL）核苷酸序列，所述重链恒定区基因序列包含CH1基因中的缺失和/或遗传工程改造的单重排列轻链的插入，其中小鼠能够 表达功能性IgM，单结构域抗原结合蛋白，例如VL-单结构域结合蛋白和基因工程重排的轻链。

    GENETICALLY MODIFIED MAJOR HISTOCOMPATIBILITY COMPLEX MICE
    8.
    发明申请
    GENETICALLY MODIFIED MAJOR HISTOCOMPATIBILITY COMPLEX MICE 审中-公开
    遗传修饰主要组织复合体系

    公开(公告)号：US20140245467A1

    公开(公告)日：2014-08-28

    申请号：US14185316

    申请日：2014-02-20

    Applicant: Regeneron Pharmaceuticals, Inc.

    Inventor： Lynn MACDONALD ,  Andrew J. MURPHY ,  Vera VORONINA ,  Cagan GURER

    IPC: A01K67/027

    CPC classification number: A01K67/0278 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2267/03 ,  C07K14/70514 ,  C07K14/70517 ,  C07K14/70539 ,  C12N15/8509

    Abstract: The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I and MHC II polypeptides and/or human or humanized β2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.

    Abstract translation: 本发明提供了表达嵌合人/非人MHC I和MHC II多肽和/或人或人源化＆lt; 2微球蛋白多肽，以及胚胎，细胞和包含其的组织的遗传修饰的非人动物。 还提供了用于制备所述转基因动物的构建体及其制备方法。 提供了使用遗传修饰动物研究人体免疫系统各个方面的方法。

    ANTI-ASIC1 ANTIBODIES AND USES THEREOF
    9.
    发明申请
    ANTI-ASIC1 ANTIBODIES AND USES THEREOF 有权
    ANTI-ASIC1抗体及其用途

    公开(公告)号：US20140056907A1

    公开(公告)日：2014-02-27

    申请号：US14068173

    申请日：2013-10-31

    Applicant: REGENERON PHARMACEUTICALS, INC.

    Inventor： Lynn MACDONALD ,  Min GAO ,  Marc R. MORRA ,  Nicole M. ALESSANDRI-HABER ,  Michael L. LaCROIX-FRALISH

    IPC: C07K16/28

    CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2317/92

    Abstract: The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. According to certain embodiments, the antibodies of the invention are selective for ASIC1 and do not bind other acid-sensing ion channels in the absence of ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders.

    Abstract translation: 本发明提供特异性结合表达酸感应离子通道-1（ASIC1）的细胞的抗体及其抗原结合片段。 根据本发明的某些实施方案，抗体在表达人ASIC1的细胞中抑制酸诱导的ASIC1介导的离子电流。 根据某些实施方案，本发明的抗体对于ASIC1是选择性的，并且在不存在ASIC1的情况下不结合其它酸感应离子通道。 本发明的抗体可用于治疗疼痛，包括与手术干预相关的疼痛以及各种疾病和病症。

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