-
公开(公告)号：US20200064355A1
公开(公告)日：2020-02-27
申请号：US16534095
申请日：2019-08-07
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Sook Yen E , Haibo QIU , Ning LI
Abstract: The present disclosure provides methods and compositions for the determining the abundance and/or concentration of protein biomarkers in a biological sample.
-
公开(公告)号：US20190231877A1
公开(公告)日：2019-08-01
申请号：US16377371
申请日：2019-04-08
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Hanne BAK , John MATTILA , Ning LI , Xiaolin TANG , Daniel DIX , Chen LI , William MARKIS
IPC: A61K47/22 , A61K39/395 , A61K47/26
CPC classification number: A61K47/22 , A61K39/39591 , A61K47/26
Abstract: The present disclosure provides a stable protein composition containing a surfactant and having less than 400 subvisible particles of 10 microns or greater diameter per container, or less than 10,000 subvisible particles of 2 microns or greater per container. A method of manufacturing such a stable protein composition is disclosed, which includes a unit of operation that removes or decreases an esterase activity that degrades the surfactant. The unit of operation may be hydrophobic interaction chromatography or filtration, mixed mode chromatography, or the like.
-
公开(公告)号：US20230063116A1
公开(公告)日：2023-03-02
申请号：US17782508
申请日：2020-12-04
Applicant: REGENERON PHARMACEUTICALS, INC.
Inventor： Joel MARTIN , Samuel DAVIS , Shawn LAWRENCE , Amy JOHNSON , Meghan CASEY , Jaimie MASTROGIACOMO , Shunhai WANG , Ning LI , Andrew TUSTIAN , Ankit VARTAK , Matthew FRANKLIN
Abstract: The present invention provides VEGF mini-trap molecules and method of treating or preventing angiogenic disorders such as angiogenic eye disorders and cancer.
-
公开(公告)号：US20210239663A1
公开(公告)日：2021-08-05
申请号：US17161803
申请日：2021-01-29
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Ming HUANG , Haibo QIU , Xiaobin XU , Ning LI
Abstract: The disclosure provides methods of characterizing a sample of oligonucleotides of interest using liquid chromatography and mass spectrometry.
-
Patent Agency Ranking
公开(公告)号：US20250161457A1
公开(公告)日：2025-05-22
申请号：US19029726
申请日：2025-01-17
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Hanne BAK , John MATTILA , Ning LI , Xiaolin TANG , Daniel B. DIX , Chen LI , William MARKIS , Mayank PATEL
IPC: A61K47/22 , A61K39/395 , A61K47/26
Abstract: The present disclosure provides a stable protein composition containing a surfactant and having less than 400 subvisible particles of 10 microns or greater diameter per container, or less than 10,000 subvisible particles of 2 microns or greater per container. A method of manufacturing such a stable protein composition is disclosed, which includes a unit of operation that removes or decreases an esterase activity that degrades the surfactant. The unit of operation may be hydrophobic interaction chromatography or filtration, mixed mode chromatography, or the like.
-
公开(公告)号：US20230366888A1
公开(公告)日：2023-11-16
申请号：US18175066
申请日：2023-02-27
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Sook Yen E , Haibo QIU , Ning LI
CPC classification number: G01N33/6851 , G16B40/10 , G16H50/30
Abstract: The present disclosure provides methods and compositions for the determining the abundance and/or concentration of protein biomarkers in a biological sample.
-
公开(公告)号：US20250060346A1
公开(公告)日：2025-02-20
申请号：US18813607
申请日：2024-08-23
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Ming HUANG , Haibo QIU , Xiaobin XU , Ning LI
Abstract: The disclosure provides methods of characterizing a sample of oligonucleotides of interest using liquid chromatography and mass spectrometry.
-
公开(公告)号：US20240415969A1
公开(公告)日：2024-12-19
申请号：US18757848
申请日：2024-06-28
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Hanne BAK , John MATTILA , Ning LI , Xiaolin TANG , Daniel B. DIX , Chen LI , William MARKIS
IPC: A61K47/22 , A61K39/395 , A61K47/26
Abstract: The present disclosure provides a stable protein composition containing a surfactant and having less than 400 subvisible particles of 10 microns or greater diameter per container, or less than 10,000 subvisible particles of 2 microns or greater per container. A method of manufacturing such a stable protein composition is disclosed, which includes a unit of operation that removes or decreases an esterase activity that degrades the surfactant. The unit of operation may be hydrophobic interaction chromatography or filtration, mixed mode chromatography, or the like.
-
9.发明申请公开(公告)号：US20160101181A1
公开(公告)日：2016-04-14
申请号：US14878079
申请日：2015-10-08
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Hanne BAK , John MATTILA , Ning LI , Xiaolin TANG , Daniel DIX , Chen LI , William MARKIS
IPC: A61K47/22 , A61K39/395
CPC classification number: A61K47/22 , A61K39/39591 , A61K47/26
Abstract: The present disclosure provides a stable protein composition containing a surfactant and having less than 400 subvisible particles of 10 microns or greater diameter per container, or less than 10,000 subvisible particles of 2 microns or greater per container. A method of manufacturing such a stable protein composition is disclosed, which includes a unit of operation that removes or decreases an esterase activity that degrades the surfactant. The unit of operation may be hydrophobic interaction chromatography or filtration, mixed mode chromatography, or the like.
Abstract translation: 本公开内容提供了包含表面活性剂并且具有每个容器具有小于或等于10微米或更大直径的小于400个可隐形颗粒的稳定的蛋白质组合物，或每个容器具有小于10,000个2微米或更大的潜在颗粒。 公开了制备这种稳定蛋白质组合物的方法，其包括除去或降低降解表面活性剂的酯酶活性的操作单元。 操作单元可以是疏水相互作用层析或过滤，混合模式色谱法等。
-
-
-
-
-
-
-
-
Search Results
9
records
(took 0.017 seconds)
