公开(公告)号：US11071787B2

公开(公告)日：2021-07-27

申请号：US15254195

申请日：2016-09-01

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： James C. Cloyd

IPC: A61K31/724 ,  A61K47/40 ,  A61K31/357 ,  A61K9/00

Abstract: The present invention is directed to compositions comprising topiramate and a sulfoalkyl ether cyclodextrin, and methods of making and using the same.

公开(公告)号：US10933042B2

公开(公告)日：2021-03-02

申请号：US16458994

申请日：2019-07-01

Applicant: Allaysis, LLC ,  Regents of the University of Minnesota

Inventor： James C. Cloyd ,  Adolfo L. Gomez ,  Linda Krach ,  Robert L. Kriel ,  John Schrogie ,  Stephen John Tucker ,  Rob Tuohy

IPC: A61K31/197 ,  A61K9/00 ,  A61P25/14 ,  A61K45/06

Abstract: An intravenous baclofen solution is disclosed, along with methods of dosing and treatment therewith.

公开(公告)号：US20250009698A1

公开(公告)日：2025-01-09

申请号：US18755956

申请日：2024-06-27

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Reena V. Kartha ,  James C. Cloyd

IPC: A61K31/201 ,  A61K47/40

Abstract: Pharmaceutical compositions including nervonic acid or a pharmaceutically acceptable salt thereof and a cyclodextrin. Methods of treating a subject having or at risk of having adrenoleukodystrophy and/or a neurological disease by administering a pharmaceutical composition of the present disclosure to the subject.

公开(公告)号：US20230248679A1

公开(公告)日：2023-08-10

申请号：US18136777

申请日：2023-04-19

Applicant: Allaysis, LLC ,  Regents of the University of Minnesota

Inventor： James C. Cloyd ,  Adolfo L. Gomez ,  Linda Krach ,  Robert L. Kriel ,  John Schrogie ,  Stephen John Tucker ,  Rob Tuohy

IPC: A61K31/197 ,  A61K9/00 ,  A61P25/14 ,  A61K45/06

CPC classification number: A61K31/197 ,  A61K9/0019 ,  A61P25/14 ,  A61K45/06

Abstract: An intravenous baclofen solution is disclosed, along with methods of dosing and treatment therewith.

公开(公告)号：US10682310B2

公开(公告)日：2020-06-16

申请号：US15559408

申请日：2016-03-17

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Ronald A. Siegel ,  Mamta Kapoor ,  Narsihmulu Cheryala ,  Gunda I. Georg ,  James C. Cloyd

IPC: A61K38/48 ,  A61K9/00 ,  A61K31/5517 ,  A61K9/12 ,  A61K31/417 ,  C07D233/64

Abstract: Certain embodiments of the invention provide a formulation suitable for nasal administration comprising water, a prodrug of a therapeutic agent, and an enzyme that is suitable for intranasal conversion of the prodrug to the therapeutic agent, as well as methods of use thereof.

公开(公告)号：US20190388373A1

公开(公告)日：2019-12-26

申请号：US16458994

申请日：2019-07-01

Applicant: Allaysis, LLC ,  Regents of the University of Minnesota

Inventor： James C. Cloyd ,  Adolfo L. Gomez ,  Linda Krach ,  Robert L. Kriel ,  John Schrogie ,  Stephen John Tucker ,  Rob Tuohy

IPC: A61K31/197 ,  A61K45/06 ,  A61P25/14 ,  A61K9/00

Abstract: An intravenous baclofen solution is disclosed, along with methods of dosing and treatment therewith.

公开(公告)号：US20220160878A1

公开(公告)日：2022-05-26

申请号：US17384616

申请日：2021-07-23

Applicant: Regents of the University of Minnesota

Inventor： James C. Cloyd

IPC: A61K47/40 ,  A61K31/357 ,  A61K31/724 ,  A61K9/00

Abstract: The present invention is directed to compositions comprising topiramate and a sulfoalkyl ether cyclodextrin, and methods of making and using the same.

公开(公告)号：US20200038353A1

公开(公告)日：2020-02-06

申请号：US16459004

申请日：2019-07-01

Applicant: Allaysis, LLC ,  Regents of the University of Minnesota

Inventor： James C. Cloyd ,  Adolfo L. Gomez ,  Linda Krach ,  Robert L. Kriel ,  John Schrogie ,  Stephen John Tucker ,  Rob Tuohy

IPC: A61K31/197 ,  A61K9/00 ,  A61P25/14 ,  A61K45/06

Abstract: An intravenous baclofen solution is disclosed, along with methods of dosing and treatment therewith.

公开(公告)号：US10350183B2

公开(公告)日：2019-07-16

申请号：US14997135

申请日：2016-01-15

Applicant: Allaysis, LLC ,  Regents of the University of Minnesota

Inventor： James C. Cloyd ,  Adolfo L. Gomez ,  Linda Krach ,  Robert L. Kriel ,  John Schrogie ,  Stephen John Tucker ,  Rob Tuohy

IPC: A61K31/197 ,  A61K9/00 ,  A61P25/14 ,  A61K45/06

Abstract: An intravenous baclofen solution is disclosed, along with methods of dosing and treatment therewith.

公开(公告)号：US20170043019A1

公开(公告)日：2017-02-16

申请号：US15254195

申请日：2016-09-01

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： James C. Cloyd

IPC: A61K47/40 ,  A61K9/00 ,  A61K31/357

CPC classification number: A61K47/40 ,  A61K9/0019 ,  A61K31/357 ,  A61K31/724 ,  A61K2300/00

Abstract: The present invention is directed to compositions comprising topiramate and a sulfoalkyl ether cyclodextrin, and methods of making and using the same.

Abstract translation: 本发明涉及包含托吡酯和磺基烷基醚环糊精的组合物及其制备和使用方法。