公开(公告)号：US20020143145A1

公开(公告)日：2002-10-03

申请号：US09774566

申请日：2001-02-01

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： F. Ivy Carroll ,  James B. Thomas ,  S. Wayne Mascarella

IPC: C07D221/02 ,  C07D241/02 ,  C07D265/30 ,  C07D279/12

CPC classification number: C07D471/08

Abstract: Structurally novel kappa opioid receptor antagonists are provided and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

Abstract translation: 提供了结构上新颖的κ阿片样物质受体拮抗剂，并且这些拮抗剂用于治疗通过κ阿片受体如海洛因或可卡因成瘾的结合而改善的疾病状态。

公开(公告)号：US20020132828A1

公开(公告)日：2002-09-19

申请号：US09755021

申请日：2001-01-08

Applicant: Research Triangle Institute

Inventor： F. Ivy Carroll ,  James B. Thomas ,  S. Wayne Mascarella

IPC: A61K031/445

CPC classification number: C07D401/12

Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors relative to nor-BNI, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

Abstract translation: 提供了卡帕阿片受体拮抗剂，其相对于nor-BNI对κ阿片受体的功能结合测定产生显着改善，以及这些拮抗剂在治疗通过κ阿片样受体如海洛因或可卡因结合而改善的疾病状态的用途 成瘾