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公开(公告)号：US20020143145A1
公开(公告)日：2002-10-03
申请号：US09774566
申请日：2001-02-01
Applicant: RESEARCH TRIANGLE INSTITUTE
Inventor： F. Ivy Carroll , James B. Thomas , S. Wayne Mascarella
IPC: C07D221/02 , C07D241/02 , C07D265/30 , C07D279/12
CPC classification number: C07D471/08
Abstract: Structurally novel kappa opioid receptor antagonists are provided and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
Abstract translation: 提供了结构上新颖的κ阿片样物质受体拮抗剂，并且这些拮抗剂用于治疗通过κ阿片受体如海洛因或可卡因成瘾的结合而改善的疾病状态。
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公开(公告)号：US20020132828A1
公开(公告)日：2002-09-19
申请号：US09755021
申请日：2001-01-08
Applicant: Research Triangle Institute
Inventor： F. Ivy Carroll , James B. Thomas , S. Wayne Mascarella
IPC: A61K031/445
CPC classification number: C07D401/12
Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors relative to nor-BNI, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
Abstract translation: 提供了卡帕阿片受体拮抗剂，其相对于nor-BNI对κ阿片受体的功能结合测定产生显着改善，以及这些拮抗剂在治疗通过κ阿片样受体如海洛因或可卡因结合而改善的疾病状态的用途 成瘾
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Patent Agency Ranking
公开(公告)号：US20040146518A1
公开(公告)日：2004-07-29
申请号：US10742782
申请日：2003-12-23
Applicant: Research Triangle Institute
Inventor： Frank I. Carroll , James B. Thomas , S. Wayne Mascarella
IPC: A61K039/00
CPC classification number: C07D221/22 , C07D211/22 , C07D211/58 , C07D221/08
Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.
Abstract translation: 本申请涉及新型阿片受体拮抗剂和激动剂，制备这些化合物的方法及其使用方法。
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公开(公告)号：US20020169324A1
公开(公告)日：2002-11-14
申请号：US10100096
申请日：2002-03-19
Applicant: Research Triangle Institute
Inventor： Frank I. Carroll , James B. Thomas , S. Wayne Mascarella
IPC: C07D211/32
CPC classification number: C07D221/22 , C07D211/22 , C07D211/58 , C07D221/08
Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.
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公开(公告)号：US20030158415A1
公开(公告)日：2003-08-21
申请号：US10266774
申请日：2002-10-09
Applicant: Research Triangle Institute
Inventor： Frank I. Carroll , James B. Thomas , S. Wayne Mascarella
CPC classification number: C07D221/22 , C07D211/22 , C07D211/58 , C07D221/08
Abstract: The present invention relates to a class of nitrogen-containing heterocyclic compounds which bind to opioid receptors. The inventive compounds can be used to treat a variety of disease states which involve the opioid receptors.
Abstract translation: 本发明涉及一类与阿片受体结合的含氮杂环化合物。 本发明化合物可用于治疗涉及阿片受体的各种疾病状态。
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公开(公告)号：US20020193602A1
公开(公告)日：2002-12-19
申请号：US10099948
申请日：2002-03-19
Applicant: Research Triangle Institute
Inventor： Frank I. Carroll , James B. Thomas , S. Wayne Mascarella
IPC: C07D211/32
CPC classification number: C07D221/22 , C07D211/22 , C07D211/58 , C07D221/08
Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.
Abstract translation: 本申请涉及新型阿片受体拮抗剂和激动剂，制备这些化合物的方法及其使用方法。
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公开(公告)号：US20020165396A1
公开(公告)日：2002-11-07
申请号：US10100097
申请日：2002-03-19
Applicant: Research Triangle Institute
Inventor： Frank I. Carroll , James B. Thomas , S. Wayne Mascarella
IPC: C07D211/32
CPC classification number: C07D221/22 , C07D211/22 , C07D211/58 , C07D221/08
Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.
Abstract translation: 本申请涉及新型阿片受体拮抗剂和激动剂，制备这些化合物的方法及其使用方法。
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