公开(公告)号：US20180134687A1

公开(公告)日：2018-05-17

申请号：US15812425

申请日：2017-11-14

申请人： RESPIVERT LIMITED

发明人： Kazuhiro Ito ,  Catherine Elisabeth Charron ,  John King-Underwood ,  Stuart Thomas Onions ,  Alistair Ian Longshaw ,  Rudy Broeckx ,  Walter Filliers ,  Alex Copmans

IPC分类号： C07D403/12 ,  A61K31/351 ,  A61K31/513 ,  A61K31/506 ,  A61K31/215 ,  C07D491/10 ,  A61K31/4155

CPC分类号： C07D403/12 ,  A61K31/215 ,  A61K31/351 ,  A61K31/4155 ,  A61K31/506 ,  A61K31/513 ,  C07B2200/13 ,  C07D491/10 ,  Y02A50/406

摘要： There is provided a compound of formula (I) which is an inhibitor of the family of p38 mitogen-activated protein kinase enzymes, and to its use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as asthma and COPD.

公开(公告)号：US10738032B2

公开(公告)日：2020-08-11

申请号：US16285762

申请日：2019-02-26

申请人： RESPIVERT LIMITED

发明人： Kazuhiro Ito ,  Catherine Elisabeth Charron ,  John King-Underwood ,  Stuart Thomas Onions ,  Alistair Ian Longshaw ,  Rudy Broeckx ,  Walter Filliers ,  Alex Copmans

IPC分类号： C07D403/12 ,  A61K31/4155 ,  C07D491/10 ,  A61K31/215 ,  A61K31/351 ,  A61K31/513 ,  A61K31/506

摘要： There is provided a compound of formula (I) which is an inhibitor of the family of p38 mitogen-activated protein kinase enzymes, and to its use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as asthma and COPD.

公开(公告)号：US10266519B2

公开(公告)日：2019-04-23

申请号：US15812425

申请日：2017-11-14

申请人： RESPIVERT LIMITED

发明人： Kazuhiro Ito ,  Catherine Elisabeth Charron ,  John King-Underwood ,  Stuart Thomas Onions ,  Alistair Ian Longshaw ,  Rudy Broeckx ,  Walter Filliers ,  Alex Copmans

IPC分类号： C07D401/14 ,  C07D403/12 ,  A61K31/4155 ,  C07D491/10 ,  A61K31/215 ,  A61K31/351 ,  A61K31/513 ,  A61K31/506

摘要： There is provided a compound of formula (I) which is an inhibitor of the family of p38 mitogen-activated protein kinase enzymes, and to its use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as asthma and COPD.

公开(公告)号：US20190185458A1

公开(公告)日：2019-06-20

申请号：US16285762

申请日：2019-02-26

申请人： RESPIVERT LIMITED

发明人： Kazuhiro ITO ,  Catherine Elisabeth Charron ,  John King-Underwood ,  Stuart Thomas Onions ,  Alistair Ian Longshaw ,  Rudy Broeckx ,  Walter Filliers ,  Alex Copmans

IPC分类号： C07D403/12 ,  A61K31/351 ,  C07D491/10 ,  A61K31/506 ,  A61K31/513 ,  A61K31/4155 ,  A61K31/215

摘要： There is provided a compound of formula (I) which is an inhibitor of the family of p38 mitogen-activated protein kinase enzymes, and to its use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as asthma and COPD.