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    Lactamimide derivatives useful as hypoglycemic agents
    3.
    发明授权
    Lactamimide derivatives useful as hypoglycemic agents 失效
    用作降血糖药的内酰胺衍生物

    公开(公告)号：US3890445A

    公开(公告)日：1975-06-17

    申请号：US45356674

    申请日：1974-03-22

    申请人： RICHARDSON MERRELL INC

    发明人： GRISAR J MARTIN ,  CLAXTON GEORGE P ,  BLOHM THOMAS R

    IPC分类号： A61K31/395 ,  A61K27/00

    CPC分类号： A61K31/395

    摘要： WHEREIN X represents oxygen or sulfur; A represents a bond, or a straight or branched alkylene chain of from 1 to 3 carbon atoms; R represents hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, a straight or branched lower alkenyl group of from 3 to 6 carbon atoms, a cycloalkyl group of from 3 to 6 carbon atoms or phenyl; R1 represents hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms; n is an integer of from 3 to 11; and pharmaceutically acceptable acid addition salts and individual optical isomers of the compounds where applicable.
    The lactamimide derivatives of this invention useful as hypoglycemic agents are represented by the formula

    摘要翻译： 用作降血糖剂的本发明的内酰胺衍生物由下式表示：WHEREIN X表示氧或硫; A表示键或具有1至3个碳原子的直链或支链亚烷基链; R代表氢，1至4个碳原子的直链或支链低级烷基，3至6个碳原子的直链或支链低级链烯基，3至6个碳原子的环烷基或苯基; R1表示氢或1〜4个碳原子的直链或支链低级烷基; n为3〜11的整数， 和化合物的药学上可接受的酸加成盐和各种旋光异构体。