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64 条记录 (耗时 0.016 秒)

    Leukotriene antagonist
    6.
    发明授权
    Leukotriene antagonist 失效

    公开(公告)号：US4730005A

    公开(公告)日：1988-03-08

    申请号：US864562

    申请日：1986-05-16

    申请人： John G. Gleason ,  Carl D. Perchonock

    发明人： John G. Gleason ,  Carl D. Perchonock

    IPC分类号： A61K31/19 ,  A61K31/38 ,  C07C45/29 ,  C07C45/44 ,  C07C45/56 ,  C07C45/62 ,  C07C45/67 ,  C07C45/68 ,  C07C45/71 ,  C07C45/72 ,  C07C47/542 ,  C07C47/546 ,  C07C47/548 ,  C07C47/55 ,  C07C47/575 ,  C07C49/86 ,  C07D333/18 ,  C07D333/36 ,  C07D333/32 ,  C07D333/24

    CPC分类号： C07D333/18 ,  A61K31/19 ,  C07C317/00 ,  C07C321/00 ,  C07C45/298 ,  C07C45/44 ,  C07C45/56 ,  C07C45/62 ,  C07C45/673 ,  C07C45/68 ,  C07C45/71 ,  C07C45/72 ,  C07C47/542 ,  C07C47/546 ,  C07C47/548 ,  C07C47/55 ,  C07C47/575 ,  C07C49/86

    摘要： The compounds represented by the following structural formula (I) ##STR1## wherein m is 1 or 2; n is 1, 2 or 3; R' is hydrogen or methyl; R is a radical selected from the group consisting of: ##STR2## wherein R.sub.1 is C.sub.8 to C.sub.13 alkyl, C.sub.7 to C.sub.12 alkoxy, C.sub.7 to C.sub.12 thioalkyl, C.sub.10 to C.sub.12 1-alkynyl, 11-dodecynyl, 1-trans-dodecenyl, 5-(4-acetyl-3-hydroxy-2-propylphenoxypentoxy, 2(Z), 5(Z)-undecadienyloxy, phenyl-C.sub.4 to C.sub.10 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenylthio-C.sub.3 to C.sub.9 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenyl-CH.dbd.CH--(CH.sub.2).sub.2-8, phenyl-C.sub.3 to C.sub.9 alkoxy, trifluoromethyl-C.sub.7 to C.sub.12 alkyl, cyclohexyl- C.sub.4 to C.sub.10 alkyl or ##STR3## wherein each q is 0, 1, 2 or 3 but the sum of both q's does not exceed 3, and R.sub.2 is hydrogen, bromo, chloro, methyl, trifluoromethyl, hydroxy, methoxy or nitro; or R.sub.1 is hydrogen and R.sub.2 is C.sub.8 to C.sub.13 alkyl, C.sub.7 to C.sub.12 alkoxy, C.sub.7 to C.sub.12 thioalkyl, C.sub.10 to C.sub.12 1-alkynyl, 11-dodecynyl, 1-trans-dodecenyl, 5-(4-acetyl-3-hydroxy-2-propylphenoxy(pentoxy, 2(Z), 5(Z)-undecadienyloxy, phenyl-C.sub.4 to C.sub.10 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenylthio-C.sub.3 to C.sub.9 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenyl-CH.dbd.CH--(CH.sub.2).sub.2-8, phenyl-C.sub.3 to C.sub.9 alkoxy, trifluoromethyl-C.sub.7 to C.sub.12 alkyl, cyclohexyl-C.sub.4 to C.sub.10 alkyl or ##STR4## wherein each q is 0, 1, 2 or 3 but the sum of both q's does not exceed 3, and p is 0 or 1, with the proviso that R is not a thiophene radical and any of R.sub.1 and R.sub.2 above are not thioalkyl or phenylthioalkyl when p is 1; and pharmaceutically acceptable salts thereof have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.

    Aldehyde-containing vinylaryl ethers
    7.
    发明授权
    Aldehyde-containing vinylaryl ethers 失效
    含醛的乙烯基芳基醚

    公开(公告)号：US4281207A

    公开(公告)日：1981-07-28

    申请号：US88705

    申请日：1979-10-26

    申请人： John C. Wilson

    发明人： John C. Wilson

    IPC分类号： C07C45/71 ,  C07C47/277 ,  C07C47/575 ,  C08F12/22 ,  C07C47/232 ,  C07C47/548

    CPC分类号： C08F12/22 ,  C07C45/71 ,  C07C47/277 ,  C07C47/575

    摘要： Disclosed herein are monomeric compounds having the formula (I): ##STR1## wherein: R, R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen or alkyl having from 1 to 4 carbon atoms;R.sup.4 is arylene having 6 to 18 carbon atoms;m is an integer from 1 to 4; andn is an integer from 0 to 4.These monomers can be homopolymerized or copolymerized with one or more other polymerizable monomers, and can particularly be copolymerized with those monomers having substituents which are susceptible to attack or degradation by a base. The resulting crosslinkable polymers are useful in relief image materials, such as photoresists and lithographic plates.

    摘要翻译： 本文公开了具有式（I）的单体化合物：其中：R，R 1，R 2和R 3独立地为氢或具有1至4个碳原子的烷基; R4是具有6-18个碳原子的亚芳基; m是1至4的整数; n为0〜4的整数。这些单体可与一种或多种其它可聚合单体均聚或共聚，特别是可与具有易受碱侵蚀或降解的取代基的单体共聚。 所得到的交联聚合物可用于浮雕图像材料，例如光致抗蚀剂和平版印刷版。