公开(公告)号：US3662062A

公开(公告)日：1972-05-09

申请号：US3662062D

申请日：1970-09-02

申请人： RICHARDSON MERRELL INC

发明人： KRUEGER RUSSELL F ,  RITTER HARRY W ,  SILL ARTHUR D

IPC分类号： C07C65/36 ,  A61K27/00

CPC分类号： C07C65/36 ,  C07C2603/18

摘要： ANTIVIRAL COMPOSITIONS AND METHODS FOR INHIBITING OR INACTIVATING VIRUSES BY SUBJECTING A HOST TO AN ANTIVIRALLY EFFECTIVE QUANTITY OF A FLUORENONE OF THE FOLLOWING FORMULA I OR ACID ADDITION SALT THEREOF.

BIS(R1-N(-R2)-A-Y-CO-)-FLUOREN-9-ONE

WHEREIN EACH Y IS OXYGEN OR SULFUR; EACH A IS ALKYLENE OF 2 TO ABOUT 8 CARBON ATOMS; AND EACH R1 AND R2 IS HYDROGEN, ALKYL OF 1 TO ABOUT 6 CARBON ATOMS, CYCLOALKYL OF 3 TO 6 CARBON ATOMS, ALKENYL OF 3 TO 6 CARBON ATOMS, OR EACH SET OF R1 AND R2 TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED CAN BE A SATURATED MONOCYCLIC HETEROCYCLIC GROUP. AN ILLUSTRATIVE FLUORENONE USED IN THE INVENTION IS BIS(3-DIBTYLAMINOPROPYL)-9-OXOFLUORENE-2,7DICARBOXYLATE DIHYDROCHLORIDE.