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    Antiviral compositions and methods of use
    1.
    发明授权
    Antiviral compositions and methods of use 失效
    有害成分和使用方法

    公开(公告)号：US3662062A

    公开(公告)日：1972-05-09

    申请号：US3662062D

    申请日：1970-09-02

    申请人： RICHARDSON MERRELL INC

    发明人： KRUEGER RUSSELL F ,  RITTER HARRY W ,  SILL ARTHUR D

    IPC分类号： C07C65/36 ,  A61K27/00

    CPC分类号： C07C65/36 ,  C07C2603/18

    摘要： ANTIVIRAL COMPOSITIONS AND METHODS FOR INHIBITING OR INACTIVATING VIRUSES BY SUBJECTING A HOST TO AN ANTIVIRALLY EFFECTIVE QUANTITY OF A FLUORENONE OF THE FOLLOWING FORMULA I OR ACID ADDITION SALT THEREOF.

    BIS(R1-N(-R2)-A-Y-CO-)-FLUOREN-9-ONE

    WHEREIN EACH Y IS OXYGEN OR SULFUR; EACH A IS ALKYLENE OF 2 TO ABOUT 8 CARBON ATOMS; AND EACH R1 AND R2 IS HYDROGEN, ALKYL OF 1 TO ABOUT 6 CARBON ATOMS, CYCLOALKYL OF 3 TO 6 CARBON ATOMS, ALKENYL OF 3 TO 6 CARBON ATOMS, OR EACH SET OF R1 AND R2 TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED CAN BE A SATURATED MONOCYCLIC HETEROCYCLIC GROUP. AN ILLUSTRATIVE FLUORENONE USED IN THE INVENTION IS BIS(3-DIBTYLAMINOPROPYL)-9-OXOFLUORENE-2,7DICARBOXYLATE DIHYDROCHLORIDE.

    Bis-basic ketones of xanthene and xanthen-9-one
    2.
    发明授权
    Bis-basic ketones of xanthene and xanthen-9-one 失效
    XANTHENE和XANTHEN-9-ONE的BIS基础证书

    公开(公告)号：US3859286A

    公开(公告)日：1975-01-07

    申请号：US9737970

    申请日：1970-12-11

    申请人： RICHARDSON MERRELL INC

    发明人： FLEMING ROBERT W ,  SILL ARTHUR D ,  SWEET FRANCIS WILLIAM

    IPC分类号： C07D311/82 ,  C07D311/86 ,  C07D87/38 ,  A61K27/00

    CPC分类号： C07D311/86 ,  C07D311/82

    摘要： D R A W I N G
    WHEREIN X is oxygen or NR4, and R4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms; or a pharmaceutically acceptable acid addition salt thereof. These compounds can be prepared by several different methods.

    WHEREIN N IS A WHOLE INTEGER FROM 4 TO 6, AND R3 is hydrogen, lower alkyl of from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; or C. the group

    WHEREIN R1 and R2 are individually hydrogen, lower alkyl having from 1 to about 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or B. the group

    Novel bis-basic ketones of xanthene and xanthen-9-one have antiviral activity when administered orally and parenterally. The compounds are represented by the following formula:

    WHEREIN Z is oxygen or H2; each A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y is A. the group

    Antiviral compositions containing bis-basic ketones of phenoxathins and methods of inhibiting viral infections therewith
    3.
    发明授权
    Antiviral compositions containing bis-basic ketones of phenoxathins and methods of inhibiting viral infections therewith 失效
    含有吩草素的双碱性酮的抗病毒组合物及其抑制病毒感染的方法

    公开(公告)号：US3882231A

    公开(公告)日：1975-05-06

    申请号：US37757273

    申请日：1973-07-09

    申请人： RICHARDSON MERRELL INC

    发明人： FLEMING ROBERT W ,  SILL ARTHUR D

    IPC分类号： A61K31/535 ,  A61K27/00

    CPC分类号： A61K31/535 ,  Y10S514/889

    摘要： Bis-basic ketones of phenoxathiins have antiviral activity when administered orally and parenterally. The compounds are represented by the following formula:

    WHEREIN A is a straight or branched alkylene chain having from one to six carbon atoms; and each Y is selected from A. the group

    WHEREIN R1 and R2 are individually selected from hydrogen, lower alkyl having from one to six carbon atoms, cycloalkyl having from three to six carbon atoms, alkenyl of from three to six carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group or B. the group

    WHEREIN N IS A WHOLE INTEGER OF FROM FOUR TO SIX AND R3 is selected from hydrogen or lower alkyl of from one to four carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; or C. the group

    WHEREIN X is oxygen or NR4, and R4 is hydrogen or lower alkyl of from one to four carbon atoms; OR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF. These compounds can be prepared by several different methods. Antiviral compositions and methods of inhibiting or inactivating viruses by administering to hosts an antivirally effective quantity of an active ingredient are disclosed herein.

    摘要翻译： 吩噻嗪的双碱酮在口服和肠胃外给药时具有抗病毒活性。 该化合物由下式表示：

    Bis-basic esters and amides of xanthene and xanthone
    4.
    发明授权
    Bis-basic esters and amides of xanthene and xanthone 失效
    西南和西南地区的基本原料和制剂

    公开(公告)号：US3859307A

    公开(公告)日：1975-01-07

    申请号：US16271671

    申请日：1971-07-14

    申请人： RICHARDSON MERRELL INC

    发明人： CARR ALBERT A ,  FLEMING ROBERT W ,  SILL ARTHUR D

    IPC分类号： C07D311/82 ,  C07D311/86 ,  C07D7/42 ,  A61K27/00 ,  C07D7/44

    CPC分类号： C07D311/86 ,  C07D311/82 ,  Y02P20/55

    摘要： Novel bis-basic esters and amides of xanthene and xanthone of the formula

    WHEREIN: Z is oxygen or H2; each of R1 and R2 is hydrogen, (lower)alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 ring carbon atoms, alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position of the alkenyl group, or each set of R1 and R2 taken together with the nitrogen atom to which they are attached is pyrrolidino, piperidino, N(lower)alkylpiperazino, or morpholino; EACH A is alkylene of 2 to about 8 carbon atoms and separates its adjacent Y and amino nitrogen by an alkylene chain of at least 2 carbon atoms; and each Y is oxygen, or

    OR A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF. These compounds can be used as pharmaceuticals for preventing or inhibiting a viral infection.

    Fluorene bis-basic esters
    7.
    发明授权
    Fluorene bis-basic esters 失效
    荧光双基糖酵母

    公开(公告)号：US3647860A

    公开(公告)日：1972-03-07

    申请号：US3647860D

    申请日：1969-01-09

    申请人： RICHARDSON MERRELL INC

    发明人： SILL ARTHUR D ,  FLEMING ROBERT W

    IPC分类号： C07C63/49 ,  C07C69/76

    CPC分类号： C07C63/49 ,  C07C2603/18

    摘要： NOVEL FLUORENE AND FLUORENOL BIS-BASIC ESTER COMPOUNDS, THEIR METHOD OF PREPARATION AND USE AS ANTIVIRAL AGENTS. THE COMPOUNDS ARE OF THE FORMULA

    9-X,BIS(R1-N(-R2)-A-OOC-)FLUORENE

    WHEREIN: (A) EACH OF R1 AND R2 IS HYDROGEN, (LOWER) ALKYL, CYCLOALKYL OF 3 TO 6 RING CARGON ATOMS, ALKENYL OF 3 TO 6 CARBON ATOMS OR EACH SET OF R1 AND R2 AKEN TOGETHER WITH THE NITROGEN TO WHICH THEY ARE ATTACHED IS PYRROLIDINO, PIPERIDINO, N - (LOWER)ALKYLPIPERAZINO OR MORPHOLINO; (B) EACH A IS ALKYLENE OF 2 TO ABOUT 8 CARBON ATOMS AND SEPARATES ITS ADJACENT OXYGEN AND NITROGEN ATOMS BY AN ALKYLENE CHAIN OF AT LEAST 2 CARBON ATOMS; AND (C) X IS H OR OH; OR A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF.