公开(公告)号：US20130164308A1

公开(公告)日：2013-06-27

申请号：US13719214

申请日：2012-12-18

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Davide Luciano FOLETTI ,  Javier Fernando CHAPARRO RIGGERS ,  Jacob Eli Gunn GLANVILLE ,  Lee Mary Beth SHAUGHNESSY ,  David Louis SHELTON ,  Pavel STROP ,  Wenwu ZHAI

IPC: C07K16/12 ,  A61K45/06 ,  A61K39/40

CPC classification number: C07K16/1271 ,  A61K39/40 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  A61K2300/00

Abstract: The present invention provides antagonizing antibodies that bind to S. aureus alpha-toxin. The invention further provides a method of obtaining such antibodies and antibody encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies for the treatment and/or prevention of staphylococcal disease, including, for example, pneumonia, bacteremia, sepsis, eye infection, and abscess.

Abstract translation: 本发明提供了结合金黄色葡萄球菌α-毒素的拮抗性抗体。 本发明还提供了获得这样的抗体和编码抗体的核酸的方法。 本发明进一步涉及使用这些抗体治疗和/或预防葡萄球菌疾病，包括例如肺炎，菌血症，败血症，眼睛感染和脓肿的治疗方法。