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公开(公告)号：US20130122020A1
公开(公告)日：2013-05-16
申请号：US13670730
申请日：2012-11-07
发明人： Shu-Hui LIU , Wei-Hsien HO , Pavel STROP , Magdalena Grazyna DORYWALSKA , Arvind RAJPAL , David Louis SHELTON , Thomas-Toan TRAN
IPC分类号： C07K16/30
CPC分类号： C07K16/28 , A61K38/08 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K16/3076 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
摘要： The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
摘要翻译： 本发明提供特异性结合滋养层细胞表面抗原-2（Trop-2）的抗体。 本发明进一步提供了包含此类抗体的抗体缀合物，编码抗体的核酸，以及获得此类抗体的方法。 本发明还涉及这些抗体和Trop-2抗体缀合物用于治疗与Trop-2表达（例如癌症）如结肠，食管，胃，头颈部，肺， 卵巢癌或胰腺癌。
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公开(公告)号：US20160257746A1
公开(公告)日：2016-09-08
申请号：US15160742
申请日：2016-05-20
发明人： Shu-Hui LIU , Wei-Hsien HO , Pavel STROP , Magdalena Grazyna DORYWALSKA , Arvind RAJPAL , David Louis SHELTON , Thomas-Toan TRAN
CPC分类号： C07K16/28 , A61K38/08 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K16/3076 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
摘要： The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
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公开(公告)号：US20140357844A1
公开(公告)日：2014-12-04
申请号：US14460871
申请日：2014-08-15
发明人： Shu-Hui LIU , Wei-Hsien HO , Pavel STROP , Magdalena Grazyna DORYWALSKA , Arvind RAJPAL , David Louis SHELTON , Thomas-Toan TRAN
CPC分类号： C07K16/28 , A61K38/08 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K16/3076 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
摘要： The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
摘要翻译： 本发明提供特异性结合滋养层细胞表面抗原-2（Trop-2）的抗体。 本发明进一步提供了包含此类抗体的抗体缀合物，编码抗体的核酸，以及获得此类抗体的方法。 本发明还涉及这些抗体和Trop-2抗体缀合物用于治疗与Trop-2表达（例如癌症）如结肠，食管，胃，头颈部，肺， 卵巢癌或胰腺癌。
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