公开(公告)号：US20100221288A1

公开(公告)日：2010-09-02

申请号：US12778530

申请日：2010-05-12

申请人： ROBERT JOHN ZAGURSKY ,  AMY WADHAMS MASI ,  BRUCE ARTHUR GREEN ,  DEB NARAYAN CHAKRAVARTI ,  DAVID PARRISH RUSSELL ,  JOSEPH LAWRENCE WOOTERS

发明人： ROBERT JOHN ZAGURSKY ,  AMY WADHAMS MASI ,  BRUCE ARTHUR GREEN ,  DEB NARAYAN CHAKRAVARTI ,  DAVID PARRISH RUSSELL ,  JOSEPH LAWRENCE WOOTERS

IPC分类号： A61K39/02 ,  C12P21/06 ,  C12N9/00 ,  C12N1/21 ,  C12N15/63 ,  C40B40/08 ,  C07H21/04 ,  C07H21/02

CPC分类号： C12N9/88 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/3156 ,  C07K2319/00 ,  C12Q1/689 ,  C12Y305/01011

摘要： The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of Streptococcus pneumoniae, wherein the open reading frames encode polypeptides that are surface localized on Streptococcus pneumoniae. Thus, the invention relates to Streptococcus pneumoniae open reading frames that encode polypeptide antigens, polypeptides, preferably antigenic polypeptides, encoded by the Streptococcus pneumoniae open reading frames, vectors comprising open reading frame sequences and cells or animals transformed with these vectors. The invention relates also to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Streptococcus pneumoniae infection. The invention finally relates to pharmaceutical compositions, in particular immunogenic compositions, for the prevention and/or treatment of bacterial infection, in particular infections with Streptococcus pneumoniae. In particular embodiments, the immunogenic compositions are used for the treatment or prevention of systemic diseases which are induced or exacerbated by Streptococcus pneumoniae. In other embodiments, the immunogenic compositions are used for the treatment or prevention of non-systemic diseases, particularly of the otitis media, which are induced or exacerbated by Streptococcus pneumoniae.

摘要翻译： 本发明涉及包含在肺炎链球菌的基因组核苷酸序列中的新鉴定的开放阅读框，其中开放阅读框编码表面定位在肺炎链球菌上的多肽。 因此，本发明涉及编码由肺炎链球菌开放阅读框编码的多肽抗原，多肽，优选抗原性多肽，包含开放阅读框序列的载体和用这些载体转化的细胞或动物的肺炎链球菌开放阅读框。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断肺炎链球菌感染的试剂盒。 本发明最终涉及用于预防和/或治疗细菌感染，特别是肺炎链球菌感染的药物组合物，特别是免疫原性组合物。 在具体实施方案中，免疫原性组合物用于治疗或预防由肺炎链球菌引起或加重的全身性疾病。 在其它实施方案中，免疫原性组合物用于治疗或预防由肺炎链球菌引起或加重的非全身性疾病，特别是中耳炎。