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公开(公告)号：US10781258B2
公开(公告)日：2020-09-22
申请号：US16134494
申请日：2018-09-18
申请人： Roche Glycart AG
发明人： Marina Bacac , Thomas Hofer , Ralf Hosse , Christiane Neumann , Christian Klein , Ekkehard Moessner , Pablo Umana , Tina Weinzierl
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：US10577429B2
公开(公告)日：2020-03-03
申请号：US14661833
申请日：2015-03-18
申请人： Roche Glycart AG
发明人： Marina Bacac , Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
IPC分类号： A61K39/395 , C07K16/40 , A61K51/10 , C07K16/30 , A61K47/68
摘要： The invention provides antibodies against Fibroblast Activation Protein (FAP) and methods of using the same.
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公开(公告)号：US20180086849A1
公开(公告)日：2018-03-29
申请号：US15655689
申请日：2017-07-20
申请人： Roche Glycart AG
发明人： Marina Bacac , Peter Bruenker , Christiane Neumann , Christian Klein , Ekkehard Moessner , Pablo Umana , Tina Weinzierl
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/2809 , C07K16/30 , C07K16/3007 , C07K16/3053 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/60 , C07K2317/64 , C07K2317/66 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2318/20 , C07K2319/00
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：US20160060357A1
公开(公告)日：2016-03-03
申请号：US14661839
申请日：2015-03-18
申请人： ROCHE GLYCART AG
发明人： Marina Bacac , Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
IPC分类号： C07K16/40 , A61K39/395 , A61K47/48
CPC分类号： C07K16/40 , A61K47/6871 , A61K51/1075 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/92
摘要： The invention provides antibodies against Fibroblast Activation Protein (FAP) and methods of using the same.
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公开(公告)号：US10253110B2
公开(公告)日：2019-04-09
申请号：US14661839
申请日：2015-03-18
申请人： Roche Glycart AG
发明人： Marina Bacac , Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
IPC分类号： A61K39/395 , C07K16/40 , A61K51/10 , C07K16/30 , A61K47/68
摘要： The invention provides antibodies against Fibroblast Activation Protein (FAP) and methods of using the same.
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6.发明申请公开(公告)号：US20140242079A1
公开(公告)日：2014-08-28
申请号：US14188486
申请日：2014-02-24
申请人： ROCHE GLYCART AG
发明人： Marina Bacac , Thomas Hofer , Ralf Hosse , Christiane Jaeger , Christian Klein , Ekkehard Moessner , Pablo Umana , Tina Weinzierl
IPC分类号： C07K16/28
CPC分类号： C07K16/2809 , A61K2039/505 , C07K16/3007 , C07K16/3053 , C07K2317/31 , C07K2317/33 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/64 , C07K2317/66 , C07K2317/71 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
摘要翻译： 本发明一般涉及用于T细胞活化和对特异性靶细胞的重新定向的新型双特异性抗原结合分子。 此外，本发明涉及编码这种双特异性抗原结合分子的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明还涉及用于产生本发明的双特异性抗原结合分子的方法以及在治疗疾病中使用这些双特异性抗原结合分子的方法。
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公开(公告)号：US11459404B2
公开(公告)日：2022-10-04
申请号：US15655689
申请日：2017-07-20
申请人： Roche Glycart AG
发明人： Marina Bacac , Peter Bruenker , Christiane Neumann , Christian Klein , Ekkehard Moessner , Pablo Umana , Tina Weinzierl
摘要： The present invention generally relates to bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：US11332545B2
公开(公告)日：2022-05-17
申请号：US16378320
申请日：2019-04-08
申请人： Roche Glycart AG
发明人： Marina Bacac , Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
摘要： The invention provides antibodies against Fibroblast Activation Protein (FAP) and methods of using the same.
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公开(公告)号：US10781257B2
公开(公告)日：2020-09-22
申请号：US16134391
申请日：2018-09-18
申请人： Roche Glycart AG
发明人： Marina Bacac , Thomas Hofer , Ralf Hosse , Christiane Neumann , Christian Klein , Ekkehard Moessner , Pablo Umana , Tina Weinzierl
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：US10155815B2
公开(公告)日：2018-12-18
申请号：US14188486
申请日：2014-02-24
申请人： Roche Glycart AG
发明人： Marina Bacac , Thomas Hofer , Ralf Hosse , Christiane Neumann , Christian Klein , Ekkehard Moessner , Pablo Umana , Tina Weinzierl
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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