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1.
公开(公告)号:US11639397B2
公开(公告)日:2023-05-02
申请号:US14269950
申请日:2014-05-05
申请人: Roche Glycart AG
摘要: The present invention relates to bispecific antibodies that specifically bind a T-cell activating antigen and a Tumor Antigen (TA), comprising a first Fab fragment and a second Fab fragment, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and wherein the bispecific antibody does not comprise a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号:US10781258B2
公开(公告)日:2020-09-22
申请号:US16134494
申请日:2018-09-18
申请人: Roche Glycart AG
发明人: Marina Bacac , Thomas Hofer , Ralf Hosse , Christiane Neumann , Christian Klein , Ekkehard Moessner , Pablo Umana , Tina Weinzierl
摘要: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号:US11459404B2
公开(公告)日:2022-10-04
申请号:US15655689
申请日:2017-07-20
申请人: Roche Glycart AG
发明人: Marina Bacac , Peter Bruenker , Christiane Neumann , Christian Klein , Ekkehard Moessner , Pablo Umana , Tina Weinzierl
摘要: The present invention generally relates to bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号:US10781257B2
公开(公告)日:2020-09-22
申请号:US16134391
申请日:2018-09-18
申请人: Roche Glycart AG
发明人: Marina Bacac , Thomas Hofer , Ralf Hosse , Christiane Neumann , Christian Klein , Ekkehard Moessner , Pablo Umana , Tina Weinzierl
摘要: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号:US10155815B2
公开(公告)日:2018-12-18
申请号:US14188486
申请日:2014-02-24
申请人: Roche Glycart AG
发明人: Marina Bacac , Thomas Hofer , Ralf Hosse , Christiane Neumann , Christian Klein , Ekkehard Moessner , Pablo Umana , Tina Weinzierl
摘要: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号:US10087250B2
公开(公告)日:2018-10-02
申请号:US14434168
申请日:2013-10-03
申请人: Roche Glycart AG
摘要: The present invention relates to bispecific antibodies comprising at least two Fab fragments, wherein the first Fab fragment comprises at least one antigen binding site specific for a first antigen; and the second Fab fragment comprises at least one antigen binding site specific for a second antigen, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged and the two Fab fragments are connected to each other by two peptide linkers; and wherein the bispecific antibody is devoid of a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号:US20170198043A1
公开(公告)日:2017-07-13
申请号:US15298675
申请日:2016-10-20
申请人: Roche Glycart AG
发明人: Johannes Auer , Peter Bruenker , Tanja Fauti , Christiane Neumann , Christian Klein , Wolfgang Schaefer , Claudio Sustmann , Pablo Umana
CPC分类号: C07K16/2809 , C07K16/3053 , C07K16/468 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/92 , C07K2319/00
摘要: The present invention generally relates to novel bispecific antigen binding molecules. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号:US20180086849A1
公开(公告)日:2018-03-29
申请号:US15655689
申请日:2017-07-20
申请人: Roche Glycart AG
发明人: Marina Bacac , Peter Bruenker , Christiane Neumann , Christian Klein , Ekkehard Moessner , Pablo Umana , Tina Weinzierl
CPC分类号: C07K16/468 , A61K2039/505 , C07K16/2809 , C07K16/30 , C07K16/3007 , C07K16/3053 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/60 , C07K2317/64 , C07K2317/66 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2318/20 , C07K2319/00
摘要: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号:US20180273643A1
公开(公告)日:2018-09-27
申请号:US15918034
申请日:2018-03-12
申请人: Roche Glycart AG
发明人: Oliver AST , Peter BRUENKER , Tanja FAUTI , Anne FREIMOSER-GRUNDSCHOBER , Christiane Neumann , Christian KLEIN , Ekkehard MOESSNER , Pablo UMANA
CPC分类号: C07K16/468 , C07K16/2809 , C07K16/2863 , C07K16/3007 , C07K16/3053 , C07K16/40 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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