公开(公告)号：US12296038B2

公开(公告)日：2025-05-13

申请号：US17279296

申请日：2019-09-25

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Yu Kitaoka ,  Mariko Iwai ,  Sho Yamashina

IPC: A61K8/67 ,  A61K8/34 ,  A61Q19/00

Abstract: Provided is a very stable topical composition. A topical composition is prepared that contains (A) from 1 to 40% by mass of at least one type selected from the group consisting of ascorbic acid and salts of ascorbic acid; (B) at least 20% by mass of a diol having three carbon atoms; (C) at least one type selected from the group consisting of tocopherol, salts of tocopherol, and derivatives of tocopherol; and (D) water, wherein the mass ratio of component (D) to component (A) is from 0.5 to 5.0 and the topical composition includes less than 20% by mass of glycol ether.