公开(公告)号：US20210052481A1

公开(公告)日：2021-02-25

申请号：US16958389

申请日：2018-12-27

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Yu KITAOKA ,  Masatoshi HAGA

IPC: A61K8/67 ,  A61K8/34 ,  A61K8/41 ,  A61Q19/08 ,  A61Q19/02

Abstract: The present invention provides an external composition superior in stability and use feeling. According to the present invention, an external composition is prepared which includes (A) at least one selected from the group consisting of an ascorbic acid and an ascorbic salt, (B) a diol having 3 carbon atoms, (C) at least one selected from the group consisting of a low-molecular-weight betaine, an organic acid salt, an inorganic acid salt, a basic amino acid, a basic amino acid salt, 3-O-ethylascorbic acid, and a 3-O-ethylascorbic acid salt, and (D) water, and a content of ethoxydiglycol of said composition is less than 30 mass %.

公开(公告)号：US20220031597A1

公开(公告)日：2022-02-03

申请号：US17279296

申请日：2019-09-25

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Yu KITAOKA ,  Mariko IWAI ,  Sho YAMASHINA

IPC: A61K8/67 ,  A61K8/34 ,  A61Q19/00

Abstract: Provided is a very stable topical composition. A topical composition is prepared that contains (A) from 1 to 40% by mass of at least one type selected from the group consisting of ascorbic acid and salts of ascorbic acid; (B) at least 20% by mass of a diol having three carbon atoms; (C) at least one type selected from the group consisting of tocopherol, salts of tocopherol, and derivatives of tocopherol; and (D) water, wherein the mass ratio of component (D) to component (A) is from 0.5 to 5.0 and the topical composition includes less than 20% by mass of glycol ether.