公开(公告)号：US3753995A

公开(公告)日：1973-08-21

申请号：US3753995D

申请日：1971-12-28

Applicant: ROUSSEL UCLAF

Inventor： MARTEL J ,  COSTEROUSSE G

IPC: C07D461/00 ,  C07D471/14 ,  C07D57/08

CPC classification number: C07D471/14 ,  C07D461/00

Abstract: THE OBJECT OF THIS INVENTION IS A NEW PROCESS OF PREPARATION OF ($) EBURNAMONINE OF THE FORMULA:

12-(O=),13A-(CH3-CH2-)-2,3,4A,5,6,12,13,13A-OCTAHYDRO-

1H-INDOLO(3,2,1-DE)PYRIDO(3,2,1-IJ)(1,5)NAPHTHYRIDINE

IT IS KNOWN THAT EBURANAMONINE HAS BEEN ISOLATED FROM SEVERAL PLANT SPECIES SUCH AS VINCA MINOR AND HUNTERIA EBURNEA. EBURNAMONINE POSSESSES INTERESTING PHARMACOLOGICAL PROPERIES, IT PROVOKES A HYPERTENSION ACCOMPANIED BY A RESPIRATORY AND CARDIAC STIMULATION AND AN INCREASE OF TONICITY. IN ADDITION, EBURNAMONINE CAN SERVE AS STARTING MATERIAL IN THE SYNTHESIS OF KNOWN ANALOGOUS COMPOUNDS DISPLAYING AN INTERESTING PHYSIOLOGICAL ACTIVITY.