公开(公告)号：US3810887A

公开(公告)日：1974-05-14

申请号：US20156471

申请日：1971-11-23

Applicant: ROUSSEL UCLAF

Inventor： SALMON J ,  BUCOURT R ,  PIERDET A

IPC: A61K31/565 ,  C07C20060101 ,  C07J1/00 ,  C07C169/08 ,  C07C173/00

CPC classification number: C07J1/0092 ,  C07J1/0096

Abstract: 11B-ALKOXY-$4-GONENES OF THE FORMULA

6-Y,7-Y'',11-(X-O-),13-R,17-(R2-O-),17-R1-GON-4-EN-3-ONE

WHEREIN R AND X ARE ALKYL OF 1 TO 4 CARBON ATOMS, R1 IS A SATURATED OR UNSATURATED HYDROCARBON OF 1 TO 6 CARBON ATOMS, R2 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND ACYL OF AN ORGANIC CARBOXYLIC ACID OF 1 TO 18 CARBON ATOMS AND Y AND Y'' ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND METHYL AND THE ENOLIC ESTERS THEREOF WITH AN ORGANIC CARBOXYLIC ACID OF 1 TO 18 CARBON ATOMS WHICH POSESS ANTI-ANDROGENIC AND ANTIESTROGENIC ACTIVITY, THEIR PREPARATION AND NOVEL INTERMEDIATES.