公开(公告)号：US20240295517A1

公开(公告)日：2024-09-05

申请号：US18572702

申请日：2022-06-23

Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY

Inventor： Sharath SRIRAM ,  Ganganath PERERA ,  Madhu BHASKARAN

IPC: G01N27/12 ,  G01N33/543 ,  G01N33/551

CPC classification number: G01N27/125 ,  G01N33/5438 ,  G01N33/551 ,  G01N2333/4737 ,  G01N2333/5412

Abstract: The invention provides a sensor for detecting a bioanalyte, comprising: a substrate; a pair of terminal electrodes disposed on the substrate in mutually spaced apart and opposing relation; and a sensing element, between and in electrical contact with the pair of terminal electrodes, wherein the sensing element comprises: (i) a semiconducting portion of the substrate, wherein the semiconducting portion comprises a high-resistivity non-oxide semiconductor and wherein a conduction path between the terminal electrodes passes through the semiconducting portion; and (ii) a bioanalyte binding site on a surface of the semiconducting portion, wherein binding of a bioanalyte to the bioanalyte binding site causes a change in electrical resistance of the sensor.

公开(公告)号：US20240288397A1

公开(公告)日：2024-08-29

申请号：US18572665

申请日：2022-06-23

Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY ,  PETER MACCALLUM CANCER INSTITUTE

Inventor： Taimur AHMED ,  Ganganath PERERA ,  Sumeet WALIA ,  Madhu BHASKARAN ,  Sharath SRIRAM ,  Stephen FOX ,  Andrew FELLOWES

IPC: G01N27/327

CPC classification number: G01N27/3275 ,  G01N27/3272

Abstract: The invention provides a sensor for detecting a nucleic acid, comprising: a substrate; a pair of terminal electrodes disposed on the substrate in mutually spaced apart and opposing relation; and a sensing element, between and in electrical contact with the pair of terminal electrodes, wherein the sensing element comprises: (i) a semiconducting portion of the substrate, wherein a conduction path between the terminal electrodes passes through the semiconducting portion; and (ii) an oligonucleotide on a surface of the semiconducting portion, the oligonucleotide being complementary to the nucleic acid to be detected, wherein hybridisation of the nucleic acid with the oligonucleotide leads to a change in resistance of the sensor.

公开(公告)号：US20230045427A1

公开(公告)日：2023-02-09

申请号：US17757700

申请日：2020-12-18

Applicant: Royal Melbourne Institute of Technology

Inventor： Taimur AHMED ,  Mortiz DOERING ,  Ganganath PERERA ,  Sumeet WALIA ,  Madhu BHASKARAN ,  Sharath SRIRAM

IPC: G01N27/327 ,  G01N33/543 ,  G01N33/563 ,  G01N33/552

Abstract: The present invention provides a sensor for detecting a bioanalyte, comprising: a substrate; a pair of terminal electrodes disposed on the substrate in mutually spaced apart and opposing relation; and a non-insulating sensing element applied to a surface of the substrate, between and in electrical contact with the pair of terminal electrodes wherein the sensing element provides a conduction path between the terminal electrodes, wherein the sensing element comprises an oxygen-deficient metal oxide layer and a bioanalyte binding site, and wherein when a voltage is applied across the sensor, an electrical signal is generated that is proportional to a change in conductance of the sensing element corresponding to binding of a bioanalyte to the bioanalyte binding site.